2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. ME-143

ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo.

For research use only. We do not sell to patients.

ME-143 Chemical Structure

ME-143 Chemical Structure

CAS No. : 852536-39-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

ME-143 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1].

IC50 & Target

NADH oxidase[1]
In Vitro

ME-143 (0-100 μM; 48 hours) reduces proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and is more potent than Genistein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ME-143 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: RKO cell; DLD1 cell
Concentration: 0-100 μM
Incubation Time: 48 hours
Result: Reduced proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and was more potent than Genistein.
In Vivo

NADH氧化酶抑制剂

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

334.37

Formula

C21H18O4
CAS No.
SMILES

OC1=CC=C2C(C3=CC=C(O)C=C3)C(C4=CC=C(O)C=C4)COC2=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ME-143 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ME-143852536-39-1NV-143ME143ME 143NV143NV 143Endogenous Metabolitesecond-generationtumor-specificNADH oxidaseWNT/β-catenincancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ME-143
Cat. No.:
HY-13675
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.