1. Stem Cell/Wnt
  2. β-catenin
    Wnt
  3. CWP232228

CWP232228 

Cat. No.: HY-18959 Purity: 98.31%
Handling Instructions

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs).

For research use only. We do not sell to patients.

CWP232228 Chemical Structure

CWP232228 Chemical Structure

CAS No. : 1144044-02-9

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5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 980 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs)[1].

IC50 & Target

Wnt/β-catenin[1]

In Vitro

CWP232228 (0.01-100 μM; 48 hours) inhibits cell proliferation with IC50 values are 2 and 0.8 μM in mouse (4T1) and human (MDA-MB-435) breast cancer cell lines, respectively[1].
CWP232228 (0.01-10 μM; 48 hours) inhibits cell proliferation with IC50s of 2.566, 2.630, and 2.596 μM in Hep3B, Huh7 and HepG2 cells, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Mouse (4T1) and human (MDA-MB-435) breast cancer cell lines
Concentration: 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 48 hours
Result: IC50s were 2 and 0.8 μM for 4T1 and MDA-MB-435 cell lines, respectively.

Cell Proliferation Assay[2]

Cell Line: Hepatocellular carcinoma cell lines HepG2, Huh7, and Hep3B
Concentration: 0.01, 0.1, 0.5, 1, 5, 10 μM
Incubation Time: 48 hours
Result: IC50s were 2.566, 2.630, and 2.596 μM for Hep3B, Huh7 and HepG2 cells, respectively.
In Vivo

CWP232228 (100 mg/kg, administered i.p.; daily; 21days for mice bearing 4T1 cell tumors; 60 days for mice bearing MDA-MB-435 cell tumors) results in a significant reduction in tumor volume[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-week-old female Balb/c and NOD/SCID mice bearing 4T1 or MDA-MB-435 cell tumors[1]
Dosage: 100 mg/kg
Administration: Administered i.p.; daily; 21days for mice bearing 4T1 cell tumors, 60 days for mice bearing MDA-MB-435 cell tumors
Result: Treatment resulted in a significant reduction in tumor volume.
Molecular Weight

717.62

Formula

C₃₃H₃₄N₇Na₂O₇P

CAS No.
SMILES

C=CCN1CC(N([[email protected]@H](CC2=CC=C(OP(O[Na])(O[Na])=O)C=C2)C(N(CC3=CC=CC4=CN(C)N=C43)C5)=O)[[email protected]]5N1C(NCC6=CC=CC=C6)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (87.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3935 mL 6.9675 mL 13.9350 mL
5 mM 0.2787 mL 1.3935 mL 2.7870 mL
10 mM 0.1393 mL 0.6967 mL 1.3935 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CWP232228CWP 232228CWP-232228β-cateninWntBeta cateninBreastliverCancerstemcellssignalingInhibitorinhibitorinhibit

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Product Name:
CWP232228
Cat. No.:
HY-18959
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