2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. SNX3-IN-1

SNX3-IN-1 is a sorting nexin 3 (SNX3) inhibitor. SNX3-IN-1 reduces SNX3 protein expression and inhibits SNX3-mediated activation of the Wnt/β-catenin signaling pathway. SNX3-IN-1 inhibits the proliferation and migration of pulmonary fibrosis-related cells, and decreases the expression of fibrosis markers α-SMA and COL-1. SNX3-IN-1 can be used in research related to pulmonary fibrosis.

For research use only. We do not sell to patients.

SNX3-IN-1

SNX3-IN-1 Chemical Structure

CAS No. : 2344793-72-0

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SNX3-IN-1 Related Antibodies

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Description

SNX3-IN-1 is a sorting nexin 3 (SNX3) inhibitor. SNX3-IN-1 reduces SNX3 protein expression and inhibits SNX3-mediated activation of the Wnt/β-catenin signaling pathway. SNX3-IN-1 inhibits the proliferation and migration of pulmonary fibrosis-related cells, and decreases the expression of fibrosis markers α-SMA and COL-1. SNX3-IN-1 can be used in research related to pulmonary fibrosis[1].

In Vitro

SNX3-IN-1 (Compound LC4) inhibits the enhanced migratory capacity of fibroblasts overexpressing SNX3[1].
SNX3-IN-1 inhibits SNX3-induced β-catenin accumulation and nuclear localization in cells[1].
SNX3-IN-1 (10 μM) inhibits TGF-β1-induced α-SMA expression in AT2 cells and fibroblasts, thereby reducing fibrotic activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SNX3-IN-1 Related Antibodies
In Vivo

SNX3-IN-1 (Compound LC4) (10 mg/kg; intratracheal administration; once weekly for 3 consecutive weeks) effectively ameliorates Wnt/β-catenin pathway activation, pulmonary function impairment and fibrosis in a mouse model of pulmonary fibrosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J Snx3-cTg mice (2 months old, male and female; spontaneous pulmonary fibrosis model); C57BL/6J N-Tg mice (2 months old, male and female; bleomycin-induced pulmonary fibrosis model)[1]
Dosage: 10 mg/kg
Administration: intratracheal; once weekly; 3 weeks
Result: Mitigated Bleomycin (BLM) (HY-108345)-induced pulmonary functional injury, reduced fibrosis areas, lowered β-catenin protein levels, and decreased hydroxyproline concentration in N-Tg mice.
Reversed fibrotic effects associated with SNX3 overexpression in Snx3-cTg mice, including reducing lung injury, fibrosis areas, and β-catenin levels.
Demonstrated therapeutic efficacy equivalent to positive control pirfenidone in inhibiting BLM-induced pulmonary fibrosis.
Molecular Weight

396.43

Formula

C23H24O6
CAS No.
Sequence

Arg-His-Arg-Thr-Pro-Met-Phe-Tyr-Gly-Leu-Met-NH2
Sequence Shortening

RHRTPMFYGLM-NH2
SMILES

O=C(C1=CC=C(OCC)C=C1O/2)C2=C\C3=CC(C)=C(OC(C)(C(O)=O)C)C(C)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SNX3-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNX3-IN-12344793-72-0Wntβ-cateninBeta cateninSNX3mouse modelsfibroblastsCOL-1Sorting nexin 3α-SMAAT2 cellspulmonary fibrosisWnt/β-catenin signalingInhibitorinhibitorinhibit

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