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E-7386 

Cat. No.: HY-111386
Handling Instructions

E-7386 is an orally active CBP/beta-catenin modulator.

For research use only. We do not sell to patients.

E-7386 Chemical Structure

E-7386 Chemical Structure

CAS No. : 1799824-08-0

Size Price Stock
1 mg USD 110 Get quote
5 mg USD 330 Get quote
10 mg USD 500 Get quote
50 mg USD 1500 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

E-7386 is an orally active CBP/beta-catenin modulator.

IC50 & Target

CBP/beta-catenin[1]

In Vivo

E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3777 mL 6.8885 mL 13.7770 mL
5 mM 0.2755 mL 1.3777 mL 2.7554 mL
10 mM 0.1378 mL 0.6888 mL 1.3777 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

The mice are treated with E-7386 (50 mg/kg, orally, BID) for three weeks. Tumor diameters are measured with digital calipers, and the tumor volume in mm3 is calculated. Immunohistochemical (IHC) analysis is evaluated for tumor-infiltrating T cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

725.85

Formula

C₃₉H₄₈FN₉O₄

CAS No.

1799824-08-0

SMILES

O=C(N([[email protected]](CN1CC2=NC(N3CC(N4CCN(CC)CC4)C3)=CC=C2)([H])N5[[email protected]@H](CC6=CC=C(O)C=C6F)C1=O)N(CC=C)CC5=O)NCC7=CC=CC=C7

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
E-7386
Cat. No.:
HY-111386
Quantity:

E-7386

Cat. No.: HY-111386