2. Stem Cell/Wnt PROTAC Cell Cycle/DNA Damage
  3. Wnt PROTACs β-catenin APC
  4. xStAx-VHLL

xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC–/– mice. xStAx-VHLL can be used as a promising anticancer agent.

For research use only. We do not sell to patients.

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xStAx-VHLL Chemical Structure

xStAx-VHLL Chemical Structure

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xStAx-VHLL Related Antibodies

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Description

xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC–/– mice. xStAx-VHLL can be used as a promising anticancer agent[1].

Molecular Weight

3231.89

Formula

C154H244N48O29
Sequence

Ac-Arg-Arg-Trp-Pro-Arg-{S5}-Ile-Leu-Asp-{S5}-His-Val-Arg-Arg-Val-Trp-Arg-{Ahx}-Ala-Leu-Ala-Pro-Tyr-Ile-Pro-NH2
Sequence Shortening

Ac-RRWPR{S5}ILD{S5}HVRRVWR-{Ahx}-ALAPYIP-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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xStAx-VHLL Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

xStAx-VHLLWntPROTACsβ-cateninAPCBeta cateninAnaphase promoting complexcolorectal cancerAPC–/– miceAPCmin/+ miceHEK293TBALB/C nude miceInhibitorinhibitorinhibit

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