1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. M435-1279

M435-1279 

Cat. No.: HY-141891
Handling Instructions

M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.

For research use only. We do not sell to patients.

M435-1279 Chemical Structure

M435-1279 Chemical Structure

CAS No. : 1359431-16-5

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Description

M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1[1].

IC50 & Target

UBE2T

 

In Vitro

M435-1279 (0, 2, 4, 8, 16, 31 μM; 48 h) significantly inhibits the growth of HGC27, AGS, and MKN45 cells[1].
M435-1279 (0, 4, 8, 12, 16, 20 μM) inhibits the cell viability with IC50s of 16.8, 11.88, 6.93, 7.76 μM of GES-1, HGC27, MKN45, AGS cells, respectively[1].
M435-1279 (31 nM to 500 μM) binds to UBE2T with a KD value of 50.5 μM[1].
M435-1279 (11.88 μM; 48 h) inhibits the ubiquitination of RACK1 and the hyperactivation of the Wnt/β-catenin pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HGC27, AGS, and MKN45 cells
Concentration: 0, 2, 4, 8, 16, 31 μM
Incubation Time: 48 h
Result: Inhibited the cell growth.

Cell Viability Assay[1]

Cell Line: HGC27, AGS, and MKN45 cells
Concentration: 0, 4, 8, 12, 16, 20 μM
Incubation Time:
Result: Inhibited the cell viability with IC50s of 16.8, 11.88, 6.93, 7.76 μM in GES-1, HGC27, MKN45, AGS cells, respectively.
In Vivo

M435-1279 (5 mg/kg/day; intratumor injection for 18 days) slows the tumor growth[1].
M435-1279 induces higher RACK1 proteins expression, and lower Ki-67 and β-catenin proteins expression in intratumor tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C nude mice CDX model (MKN45 tumor size: 75–100 mm3)[1]
Dosage: 5 mg/kg/day
Administration: Intratumor injection for 18 days
Result: Slowed the tumor growth.
Induced higher RACK1 proteins expression, and lower Ki-67 and β-catenin proteins expression in intratumor tumors.
Molecular Weight

419.47

Formula

C₁₈H₁₇N₃O₅S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
M435-1279
Cat. No.:
HY-141891
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