Regiafuran C
For research use only. We do not sell to patients.
- CAS No.: 2059921-60-5
- Formula: C25H28O5
- Molecular Weight:408.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Regiafuran C (10-40 μM; 24 h) shows no cytotoxicity against human renal proximal tubular HK-2 cells, but dose-dependently reduces the expressions of fibronectin, type I collagen, N-cadherin and vimentin in human renal proximal tubular HK-2 cells stimulated by TGF-β1[1].
Regiafuran C (10-40 μM; 24 h) inhibits the activation of the TGF-β/Smad signaling pathway in TGF-β1-stimulated human renal proximal tubular HK-2 cells in a dose-dependent manner, and reduces the levels of Wnt1, Wnt3a, GSK-3β, β-catenin, MMP7, MMP9, TGF-βRII, TGF-β1, p-Smad3, p-Smad2 and Smad4[1].
Regiafuran C (40 μM; 24 h) significantly reduces the mRNA expression levels of fibronectin, type I collagen, N-cadherin and vimentin in TGF-β1-induced human renal proximal tubular HK-2 cells[1].
Regiafuran C (40 μM; 24 h) reduces the protein levels of fibronectin, type I collagen, N-cadherin, and vimentin in TGF-β1-stimulated human renal proximal tubular HK-2 cells, as determined by immunofluorescence staining[1].
Regiafuran C (40 μM; 24 h) blocks the interaction between Smad3 and TGF-βRII in TGF-β1-stimulated human renal proximal tubular HK-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human renal proximal tubular HK-2 cells, TGF-β1-stimulated human renal proximal tubular HK-2 cells
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Concentration:10-40 μM
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Incubation Time:24 h (co-incubated with TGF-β1)
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Result:Maintained cell viability at ≥90% of control levels across all tested concentrations.
Dose-dependently downregulated TGF-β1-induced upregulation of fibronectin, collagen I, N-cadherin, and vimentin.\nDose-dependently downregulated TGF-β1-induced upregulation of TGF-βRII, TGF-β1, p-Smad3, p-Smad2, and Smad4.\nDose-dependently downregulated TGF-β1-induced upregulation of Wnt1, Wnt3a, GSK-3β, β-catenin, MMP7, and MMP9.
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Cell Line:TGF-β1-stimulated human renal proximal tubular HK-2 cells
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Concentration:40 μM
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Incubation Time:24 h (co-incubated with TGF-β1)
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Result:Significantly reduced TGF-β1-induced upregulation of fibronectin, collagen I, N-cadherin, and vimentin mRNA levels.
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Cell Line:TGF-β1-stimulated human renal proximal tubular HK-2 cells
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Concentration:40 μM
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Incubation Time:24 h (co-incubated with TGF-β1)
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Result:Reduced the increased fluorescence intensity of fibronectin, collagen I, N-cadherin, and vimentin induced by TGF-β1 stimulation.\nReduced the increased fluorescence intensity of TGF-β1 and β-catenin induced by TGF-β1 stimulation.
Chemical Information
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CAS No. 2059921-60-5
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Molecular Weight 408.49
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Formula C25H28O5
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SMILES
OC1=CC(C2=CC3=C(OC)C(C/C=C(CC/C=C(C)\C)\C)=C(O)C=C3O2)=CC(O)=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wei QH, et al. Sang-Bai-Pi extract and its constituent regiafuran C ameliorate renal fibrosis through TGF-β/Smad and Wnt/β-catenin signaling pathways. Phytomedicine. 2025;136:156351. [Content Brief]
[2]. Kyekyeku JO, et al. Prenylated 2-arylbenzofuran derivatives with potent antioxidant properties from Chlorophora regia (Moraceae). Fitoterapia. 2016;108:41-47. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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