2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad TGF-β Receptor
  4. Regiafuran C

Regiafuran C is a compound with both TGF-βRI inhibitory and anti-fibrotic activities. Regiafuran C effectively inhibits renal fibrosis by binding to TGF-βRI and interfering with the TGF-β/Smad and Wnt/β-catenin signaling pathways. Regiafuran C also exhibits free radical scavenging activity, but shows no anti-inflammatory activity in PGE2 competitive enzyme immunoassays. The ability of Regiafuran C to specifically block the Smad3-TGF-βRII interaction and inhibit fibrotic processes allows its use in renal fibrosis research.

For research use only. We do not sell to patients.

Regiafuran C

Regiafuran C Chemical Structure

CAS No. : 2059921-60-5

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Regiafuran C Related Antibodies

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Description

Regiafuran C is a compound with both TGF-βRI inhibitory and anti-fibrotic activities. Regiafuran C effectively inhibits renal fibrosis by binding to TGF-βRI and interfering with the TGF-β/Smad and Wnt/β-catenin signaling pathways. Regiafuran C also exhibits free radical scavenging activity, but shows no anti-inflammatory activity in PGE2 competitive enzyme immunoassays. The ability of Regiafuran C to specifically block the Smad3-TGF-βRII interaction and inhibit fibrotic processes allows its use in renal fibrosis research[1][2].
In Vitro

Regiafuran C (10-40 μM; 24 h) shows no cytotoxicity against human renal proximal tubular HK-2 cells, but dose-dependently reduces the expressions of fibronectin, type I collagen, N-cadherin and vimentin in human renal proximal tubular HK-2 cells stimulated by TGF-β1[1].
Regiafuran C (10-40 μM; 24 h) inhibits the activation of the TGF-β/Smad signaling pathway in TGF-β1-stimulated human renal proximal tubular HK-2 cells in a dose-dependent manner, and reduces the levels of Wnt1, Wnt3a, GSK-3β, β-catenin, MMP7, MMP9, TGF-βRII, TGF-β1, p-Smad3, p-Smad2 and Smad4[1].
Regiafuran C (40 μM; 24 h) significantly reduces the mRNA expression levels of fibronectin, type I collagen, N-cadherin and vimentin in TGF-β1-induced human renal proximal tubular HK-2 cells[1].
Regiafuran C (40 μM; 24 h) reduces the protein levels of fibronectin, type I collagen, N-cadherin, and vimentin in TGF-β1-stimulated human renal proximal tubular HK-2 cells, as determined by immunofluorescence staining[1].
Regiafuran C (40 μM; 24 h) blocks the interaction between Smad3 and TGF-βRII in TGF-β1-stimulated human renal proximal tubular HK-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Regiafuran C Related Antibodies

Western Blot Analysis[1]

Cell Line: human renal proximal tubular HK-2 cells, TGF-β1-stimulated human renal proximal tubular HK-2 cells
Concentration: 10-40 μM
Incubation Time: 24 h (co-incubated with TGF-β1)
Result: Maintained cell viability at ≥90% of control levels across all tested concentrations.
Dose-dependently downregulated TGF-β1-induced upregulation of fibronectin, collagen I, N-cadherin, and vimentin.\nDose-dependently downregulated TGF-β1-induced upregulation of TGF-βRII, TGF-β1, p-Smad3, p-Smad2, and Smad4.\nDose-dependently downregulated TGF-β1-induced upregulation of Wnt1, Wnt3a, GSK-3β, β-catenin, MMP7, and MMP9.

Real Time qPCR[1]

Cell Line: TGF-β1-stimulated human renal proximal tubular HK-2 cells
Concentration: 40 μM
Incubation Time: 24 h (co-incubated with TGF-β1)
Result: Significantly reduced TGF-β1-induced upregulation of fibronectin, collagen I, N-cadherin, and vimentin mRNA levels.

Immunofluorescence[1]

Cell Line: TGF-β1-stimulated human renal proximal tubular HK-2 cells
Concentration: 40 μM
Incubation Time: 24 h (co-incubated with TGF-β1)
Result: Reduced the increased fluorescence intensity of fibronectin, collagen I, N-cadherin, and vimentin induced by TGF-β1 stimulation.\nReduced the increased fluorescence intensity of TGF-β1 and β-catenin induced by TGF-β1 stimulation.
Molecular Weight

408.49

Formula

C25H28O5
CAS No.
SMILES

OC1=CC(C2=CC3=C(OC)C(C/C=C(CC/C=C(C)\C)\C)=C(O)C=C3O2)=CC(O)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Regiafuran C Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Regiafuran C2059921-60-5TGF-beta/SmadTGF-β ReceptorTransforming growth factor betaTransforming growth factor beta receptorsTGF-β/Smad pathwayWnt/β-catenin pathwaycollagen ISmad3TGF-βRIIN-cadherinTGF-βRIfibronectinHK-2 cellsrenal fibrosisInhibitorinhibitorinhibit

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