2059921-60-5
Chemical Structure
Regiafuran C
- CAS No.: 2059921-60-5
- Formula:C25H28O5
- Molecular Weight:408.49
InChIKey: BYCZHKBMLJHFHW-LZYBPNLTSA-N
SMILES: OC1=CC(C2=CC3=C(OC)C(C/C=C(CC/C=C(C)\C)\C)=C(O)C=C3O2)=CC(O)=C1
Biological Activity:
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Regiafuran C | Regiafuran C is a compound with both TGF-βRI inhibitory and anti-fibrotic activities. Regiafuran C effectively inhibits renal fibrosis by binding to TGF-βRI and interfering with the TGF-β/Smad and Wnt/β-catenin signaling pathways. Regiafuran C also exhibits free radical scavenging activity, but shows no anti-inflammatory activity in PGE2 competitive enzyme immunoassays. The ability of Regiafuran C to specifically block the Smad3-TGF-βRII interaction and inhibit fibrotic processes allows its use in renal fibrosis research. |
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References
- [1]. Wei QH, et al. Sang-Bai-Pi extract and its constituent regiafuran C ameliorate renal fibrosis through TGF-β/Smad and Wnt/β-catenin signaling pathways. Phytomedicine. 2025;136:156351. [Content Brief]
- [2]. Kyekyeku JO, et al. Prenylated 2-arylbenzofuran derivatives with potent antioxidant properties from Chlorophora regia (Moraceae). Fitoterapia. 2016;108:41-47. [Content Brief]
