2. Apoptosis
  3. Apoptosis
  4. JBC117

JBC117 is a novel anticancer lead compound targeting Pygo2 PHD. JBC117 can effectively antagonize the cell effect of β-catenin-dependent activity and inhibit the migration and invasion of cancer cells. JBC117 can induce apoptosis.

For research use only. We do not sell to patients.

JBC117 Chemical Structure

JBC117 Chemical Structure

CAS No. : 1214531-21-1

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JBC117 Related Antibodies

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Description

JBC117 is a novel anticancer lead compound targeting Pygo2 PHD. JBC117 can effectively antagonize the cell effect of β-catenin-dependent activity and inhibit the migration and invasion of cancer cells. JBC117 can induce apoptosis[1].

In Vitro

JBC117 (20 μM, 24 h) inhibits the growth of colon cancer (HCT116) and lung cancer (A549) with IC50 values of 2.6 and 3.3 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JBC117 Related Antibodies

Western Blot Analysis[1]

Cell Line: HCT116, A549
Concentration: 5, 10, 20 μM
Incubation Time: 72 h
Result: Downregulated the expression level of Wnt downstream target genes, including Axin2, c-myc and cyclin D1.

Cell Invasion Assay[1]

Cell Line: HCT116, A549
Concentration: 20 μM
Incubation Time: 24 h
Result: Decreased the ability to migrate and invasion in a dose-dependent manner.
In Vivo

JBC117 (20 mg/kg/ day, subcutaneously injected for 14 days) shows antitumor activity in mouse xenotransplantation models of colon cancer and lung cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse xenograft models of colon and lung cancer[1]
Dosage: 20 mg/kg
Administration: s.c. for 14 days
Result: Reduced colon and lung tumor growth by 65% and 93%, respectively.
Increased apoptosis in the tumor sections.
Molecular Weight

442.55

Formula

C28H30N2O3
CAS No.
SMILES

OC(CN1CCC2(CC1)OC3=C(C(C2)O)C=CC4=C3C=CC=C4)C5=CNC6=C5C=CC(C)=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JBC117 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBC1171214531-21-1JBC 117JBC-117ApoptosisPygo2 PHDHCT116A549AntitumorInhibitorinhibitorinhibit

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