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Adenylate cyclase 3 Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (85) Guanylate Cyclase (88) PACAP Receptor (4) 5-HT Receptor (12) ABA Receptor (1) ADC Antibody (1) Adenosine Receptor (6) Adiponectin Receptor (1) Adrenergic Receptor (15) Aminoacyl-tRNA Synthetase (3) AMPK (2) Amyloid-β (9) Antibiotic (4) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (18) Arrestin (1) ATP Synthase (1) Autophagy (9) Bacterial (15) Biochemical Assay Reagents (10) c-Kit (1) Calcium Channel (12) Calmodulin (1) Caspase (1) CD38 (3) CD47 (3) CGRP Receptor (2) Collagen (1) COX (2) CRFR (1) CXCR (1) DNA/RNA Synthesis (7) Dopamine Receptor (12) Dopamine Transporter (4) Drug Derivative (1) Drug Intermediate (2) Drug Isomer (1) Drug Metabolite (1) EGFR (2) Endogenous Metabolite (19) Endothelin Receptor (1) Environmental Pollutants (3) ERK (4) Estrogen Receptor/ERR (3) Fluorescent Dye (2) Fungal (5) FXR (3) GABA Receptor (1) GCGR (2) Glutamate Dehydrogenase (GLDH) (1) GPR171 (1) Histamine Receptor (1) HSP (2) Huntingtin (1) IKK (5) Interleukin Related (2) Isotope-Labeled Compounds (9) JAK (1) Keap1-Nrf2 (5) LDLR (1) Melanocortin Receptor (2) mGluR (1) Microtubule/Tubulin (5) Mitochondrial Metabolism (1) Mitophagy (5) Monoamine Oxidase (9) mRNA (1) Neuropeptide FF Receptor (1) Neurotensin Receptor (1) NF-κB (2) NO Synthase (11) Nucleoside Antimetabolite/Analog (7) Opioid Receptor (2) Organoid (2) Oxytocin Receptor (1) P2X Receptor (4) P2Y Receptor (8) p38 MAPK (2) Parasite (4) PGC-1α (1) Phosphodiesterase (PDE) (6) PKA (3) PKC (3) PKG (1) Potassium Channel (5) PPAR (1) Prostaglandin Receptor (5) PTHR (1) Ras (1) Reactive Oxygen Species (ROS) (3) Reference Standards (33) Sirtuin (6) Sodium Channel (1) Somatostatin Receptor (3) TGF-β Receptor (1) Thyroid Hormone Receptor (2) TRP Channel (3)
By Research Areas:	Cancer (59) Cardiovascular Disease (96) Endocrinology (16) Infection (36) Inflammation/Immunology (48) Metabolic Disease (44) Neurological Disease (89)
Click Chemistry:	Azide (1)
Oligonucleotides:	Chemokine & Receptors (1) Nucleoside Analogs (1) Nucleotide Analogs (10) mRNA (1) Adenine Nucleotide (7)

316

Inhibitors & Agonists

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GMP Molecules

Targets Recommended: Adenylate Cyclase Guanylate Cyclase Serpin PACAP Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15371

Forskolin Maximum Cited Publications 210 Publications Verification Coleonol; Colforsin; HL 362	Organoid Adenylate Cyclase FXR Autophagy PKC	Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Forskolin (Coleonol) is a potent **adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀** of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR ^[3]. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-W010918

Adenosine 5'-diphosphate 5+ Cited Publications Adenosine diphosphate; ADP	Endogenous Metabolite	Others
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-100396

SQ22536 35+ Cited Publications	Adenylate Cyclase	Metabolic Disease
SQ22536 is an effective **adenylate cyclase** (AC) inhibitor.

HY-P0221

PACAP (1-38), human, ovine, rat 5 Publications Verification Pituitary Adenylate cyclase Activating Polypeptide 38	PACAP Receptor ERK EGFR Reactive Oxygen Species (ROS) Calcium Channel	Infection Neurological Disease
PACAP (1-38), human, ovine, rat is a PAC₁ receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research ^[3] .

HY-17592

Bithionol 3 Publications Verification	Environmental Pollutants Bacterial Parasite	Infection Cancer
Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC₅₀: 4 μM) .

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide 1 Publications Verification	Adenylate Cyclase PTHR	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is an endogenous PTH2 receptor agonist and antihypertensive agent. TIP 39, Tuberoinfundibular Neuropeptide selectively activates the PTH2 receptor with no activity on the PTH1 receptor, stimulates cAMP production, activates adenylate cyclase, and elevates intracellular calcium levels via mobilization from intracellular stores. TIP 39, Tuberoinfundibular Neuropeptide is highly conserved in humans, mice, and rats. TIP 39, Tuberoinfundibular Neuropeptide is applicable to research related to nociception and inflammation-induced pain ^[3].

HY-135878

2',5'-Dideoxyadenosine 5 Publications Verification	Adenylate Cyclase Adrenergic Receptor	Metabolic Disease
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC₅₀ of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart .

HY-137167

Guanylyl imidodiphosphate lithium Gpp(NH)p lithium	Adenylate Cyclase	Metabolic Disease
Guanylyl imidodiphosphate lithium (Gpp (NH) p lithium) is a non-hydrolyzable GTP analog. Guanylyl imidodiphosphate lithium increases adenylate cyclase activity. Guanylyl imidodiphosphate lithium binds to and irreversibly activates G proteins ^[3].

HY-B1124

Fipexide 1 Publications Verification	Adenylate Cyclase Dopamine Transporter	Neurological Disease
Fipexide, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide reduces striatal **adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic** neurotransmission. Fipexide is used for senile dementia research. Fipexide acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection .

HY-W010791

Adenosine 5'-diphosphate sodium salt 5+ Cited Publications	Endogenous Metabolite	Others
Adenosine 5'-diphosphate sodium salt is a nucleoside diphosphate and the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase through its action on P_2T-purinergic receptors .

HY-100767

Guanylyl Imidodiphosphate trisodium Guanosine 5'-[β,γ-imido]triphosphate trisodium	Adenylate Cyclase	Endocrinology
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of **adenylate cyclase**. Imidodiphosphate trisodium can be used in protein synthesis studies ^[3].

HY-127137

Adenylosuccinic acid Adenylosuccinate; Aspartyl Adenylate	Endogenous Metabolite	Metabolic Disease
Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD) .

HY-103185

CCPA 1 Publications Verification 2-Chloro-N6-cyclopentyladenosine	Adenosine Receptor Adenylate Cyclase	Cardiovascular Disease Neurological Disease
CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a K_i of 0.4 nM. CCPA inhibits **adenylate cyclase with an IC₅₀** of 33 nM. CCPA exhibits anti-seizure and cardiacprotective activity. CCPA can be used for the research of seizure and myocardial infarction ^[3].

HY-P3617

Glucagon (22-29)	GCGR	Metabolic Disease
Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca ²⁺ pump in liver plasma membranes independently of adenylate cyclase activation .

HY-17500

Ataciguat 1 Publications Verification HMR-1766	Guanylate Cyclase	Cardiovascular Disease
Ataciguat (HMR-1766) is a nitric oxide-independent *soluble guanylate cyclase* (sGC)** activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects ^[3].

HY-136780

SEN177	Amyloid-β Apoptosis CD47 Huntingtin	Neurological Disease Cancer
SEN177 is an orally effect glutamine cyclase (QC) inhibitor. The K_i of SEN177 for human glutamine cyclase (hQC) is 20 nM, and the IC₅₀ is 13 nM. SEN177 interferes with the interaction between CD47 and SIRRPα, and has anti-tumor activity. SEN177 reduces aggregation and apoptosis caused by HTT mutation in Huntington model, and can be used in the study of neurodegenerative diseases ^[3].

HY-P0004

Lysipressin 2 Publications Verification Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase Oxytocin Receptor	Cardiovascular Disease Neurological Disease
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs. Lysipressin activates Oxytocin receptors and *adenylate-cyclase*. Lysipressin adjusts blood pressure and heart rate. Lysipressin shows antinociceptive activity ^[3] .

HY-135490

Reproterol	Adrenergic Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
Reproterol is a selective β2-adrenoceptor agonist and cAMP phosphodiesterase (PDE) inhibitor. Reproterol inhibits adenylate cyclase-induced phosphodiesterase activity. Reproterol inhibits histamine release from mast cells. Reproterol is applicable to research related to asthma .

HY-15371R

Forskolin (Standard) Coleonol (Standard); Colforsin (Standard); HL 362 (Standard)	Organoid Reference Standards Adenylate Cyclase FXR Autophagy PKC	Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Forskolin (Standard) is the analytical standard of Forskolin. This product is intended for research and analytical applications. Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR ^[3]. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-116530

9-Cyclopentyladenine monomethanesulfonate 9-CP-Ade mesylate	Adenylate Cyclase	Others Neurological Disease
9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive **adenylate cyclase** inhibitor with cell permeable properties .

HY-101862

CB-7921220	Adenylate Cyclase	Cardiovascular Disease Neurological Disease
CB-7921220 is an **adenylate cyclase** inhibitor.

HY-B1124A

Fipexide hydrochloride 1 Publications Verification	Adenylate Cyclase Dopamine Transporter	Neurological Disease
Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide hydrochloride reduces striatal **adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission**. Fipexide hydrochloride is used for senile dementia research. Fipexide hydrochloride acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection .

HY-146356

*Adenylyl cyclase* type 2 agonist-1**	Adenylate Cyclase	Inflammation/Immunology
Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of *adenylyl cyclase* type 2 (AC2) with the EC₅₀** of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases .

HY-W021162

*Guanylate cyclase-IN-1*	Guanylate Cyclase	Cardiovascular Disease
Guanylate cyclase-IN-1 (Example 46) is a guanylate cyclase inhibitor that can be used for cardiovascular diseases research .

HY-107547

BPIPP	Guanylate Cyclase Adenylate Cyclase	Metabolic Disease
BPIPP is a *guanylyl cyclase* type C (GC-C)** and adenylyl cyclase inhibitor that can suppress cyclic nucleotide synthesis. BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases, and has the potential for diarrhea research .

HY-P3769

Prepro-ANF (56-92), human	Guanylate Cyclase	Cardiovascular Disease
Prepro-ANF (56-92), human is a human atrial natriuretic factor precursor. Prepro-ANF (56-92), human is also a guanylate cyclase activator that enhances particulate guanylate cyclase activity in the renal membrane and renal unit .

HY-159627A

Met-AMS TEA	Bacterial	Infection
Met-AMS TEA (compound 50), a sulfamate analogue of methionyl adenylate, is a potent Escherichia coli methionyl-tRNA synthetase (MetRS) inhibitor (IC₅₀ of 7 nM) .

HY-15371G

Forskolin Coleonol; Colforsin; HL 362	Adenylate Cyclase FXR Autophagy PKC	Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Forskolin (Coleonol) (GMP) is a potent **adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀** of 0.5 μM for type I adenylyl cyclase . Forskolin (GMP) is also an inducer of intracellular cAMP formation . Forskolin (GMP) induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR ^[3]. Forskolin (GMP) exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin (GMP) also induces autophagy .

HY-P3099

Uroguanylin (human)	Guanylate Cyclase	Cancer
Uroguanylin (human) is a natural ligand for the *Guanylyl Cyclase* (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor** actions in an animal model for human colon cancer .

HY-129421

PA-9	PACAP Receptor	Neurological Disease Inflammation/Immunology
PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC₅₀ of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain .

HY-P4697A

pTH (44-68) (human) TFA	Thyroid Hormone Receptor	Endocrinology
pTH (44-68) (human) TFA is a fragment of human parathyroid hormone (pTH) that lacks the adenylate cyclase-stimulating activity of intact pTH. pTH (44-68) (human) TFA can be used to study the mechanism of action of pTH .

HY-N10772

Albanin A	Calcium Channel Calmodulin Adenylate Cyclase	Neurological Disease Inflammation/Immunology
Albanin A, a flavonoid, suppresses glutamate release by decreasing *Ca ²⁺/calmodulin/adenylate* Cyclase 1 (AC1)** activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity .

HY-127137A

Adenylosuccinic acid tetraammonium Adenylosuccinate tetraammonium; Aspartyl Adenylate tetraammonium	Endogenous Metabolite	Metabolic Disease
Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) is an orally active purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid tetraammonium can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid tetraammonium has the potential for the study of duchenne muscular dystrophy(DMD) .

HY-P0004A

Lysipressin acetate 2 Publications Verification Lysine vasopressin acetate; [Lys8]-Vasopressin acetate	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-P3689

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat	CGRP Receptor Adenylate Cyclase	Others
[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and **adenylate cyclase**. Calcitonin is mainly produced by thyroid C cells while CGRP is secreted and stored in the nervous system .

HY-121185

Hexoprenaline	Adrenergic Receptor	Infection Neurological Disease Inflammation/Immunology Endocrinology
Hexoprenaline is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline can dilate the bronchi. Hexoprenaline can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline exhibits anti-infection and anti-inflammmation effect. Hexoprenaline can increase placental weight and blood flow. Hexoprenaline can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds ^[3] .

HY-113273

Ap5A Diadenosine pentaphosphate	Endogenous Metabolite	Cancer
Ap5A (Diadenosine pentaphosphate), a diadenosine polyphosphate, is an adenylate kinase inhibitor with a K_i of 2.5 nM. Ap5A can be used for study of cancer .

HY-P3117

PACAP (6-27) (human, ovine, rat) Pituitary Adenylate cyclase-activating peptide (6-27)	Adenylate Cyclase	Neurological Disease
PACAP (6-27) (human, ovine, rat) is a PACAP receptor antagonist that blocks the canine adrenal catecholamine response to exogenous vasoactive intestinal peptide (VIP). PACAP (6-27) (human, ovine, rat) has the potential to study cardiovascular and neurological diseases .

HY-151132

Glutaminyl cyclases-IN-1 IsoQC-IN-1	CD47	Cancer
Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent *glutaminyl cyclases* (QC) inhibitor with IC₅₀** values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages .

HY-401913

endo CNTinh-03	Phosphodiesterase (PDE)	Infection Cancer
Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC₅₀ is 4 μM). Endo CNTinh-03 inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model .

HY-P5077A

Guanylin (mouse, rat) TFA	Guanylate Cyclase	Metabolic Disease
Guanylin (mouse, rat) TFA, a petide, is composed of 15 amino acids. Guanylin (mouse, rat) TFA is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) TFA can be used for the research of diarrhea .

HY-P3099A

Uroguanylin (human) TFA	Guanylate Cyclase	Cancer
Uroguanylin (human) (TFA) is a natural ligand for the *Guanylyl Cyclase* (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) (TFA) has anti-tumor** actions in an animal model for human colon cancer .

HY-12132

DMP 904	CRFR Adenylate Cyclase	Neurological Disease
DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated **adenylate cyclase** activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity .

HY-P99004

hMC1R agonist 1	Melanocortin Receptor	Inflammation/Immunology
hMC1R agonist 1 is a selective hMC1R agonist. hMC1R agonist 1 activates **adenylate cyclase** to induce intracellular cAMP accumulation. hMC1R agonist 1 can be used for the research of immune-inflammatory disorders .

HY-112269

*Glutaminyl Cyclase* Inhibitor 1**	Amyloid-β	Neurological Disease
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor with an IC₅₀ of 0.5 μM.

HY-134353A

ADP-β-S trisodium Adenosine 5'-(β-thiodiphosphate) trisodium	Interleukin Related P2Y Receptor NF-κB Caspase	Neurological Disease Inflammation/Immunology Cancer
ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes .

HY-131789A

2-NH2-PuTP sodium n2h6ATP sodium	Adenylate Cyclase	Metabolic Disease
2-NH2-PuTP (n2h6ATP) sodium, an ATP (HY-B2176) analogue, is a competitive pyruvate-stimulated **adenylate cyclase inhibitor with a K_i** of 1.7 mM.

HY-P991123

Bocunebart ALD1910; LU AG-09222	Adenylate Cyclase	Inflammation/Immunology
Bocunebart is a humanized monoclonal antibody targeting human adenylate cyclase-activating polypeptide (ADCYAP1). Bocunebart exerts anti-inflammatory activity by specifically binding to ADCYAP1 and inhibiting related inflammatory signaling pathways. Bocunebart is promising for research of inflammation-related diseases .

HY-D0882

Adenosine 5'-diphosphate dicyclohexylammonium	Biochemical Assay Reagents	Cardiovascular Disease
Adenosine 5'-diphosphate dicyclohexylammonium is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate dicyclohexylammonium induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors .

HY-P1158

[Ala2,8,9,11,19,22,24,25,27,28]-VIP	Adenylate Cyclase	Neurological Disease
[Ala2,8,9,11,19,22,24,25,27,28]-VIP is an analog vasoactive intestinal polypeptide (VIP) with high affinity and selectivity for human VIP/pituitary adenylate cyclase-activating polypeptide 1 (hVPAC1). VIP is a widespread neurotransmitter .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15371

Forskolin Maximum Cited Publications 210 Publications Verification Coleonol; Colforsin; HL 362	Classification of Application Fields Terpenoids Labiatae Metabolic Disease Diterpenoids Plants Inflammation/Immunology Disease Research Fields Endocrinology Pueraria montana (Lour.) Merr. Source Classification	Organoid Adenylate Cyclase FXR Autophagy PKC
Forskolin (Coleonol) is a potent **adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀** of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR ^[3]. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-16561

Resveratrol 155+ Cited Publications trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Vitis vinifera cv. Zalema Plants Vitaceae Infection Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501) is a CNS-penetrant natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator ^[3] . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-W010918

Adenosine 5'-diphosphate 5+ Cited Publications Adenosine diphosphate; ADP	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-16561R

Resveratrol (Standard) 155+ Cited Publications trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	Reference Standards IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator ^[3] . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-Y0265

Isatin Indoline-2,3-dione	Cardiovascular Disease Alkaloids other families Neurological Disease Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification	Monoamine Oxidase Apoptosis
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system ^[3].

HY-127137

Adenylosuccinic acid Adenylosuccinate; Aspartyl Adenylate	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD) .

HY-N7395

Cyclic ADP-ribose 1 Publications Verification cADPR	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels ^[3].

HY-P0004

Lysipressin 2 Publications Verification Lysine vasopressin; [Lys8]-Vasopressin	Monophenols Animals Classification of Application Fields Other Diseases Phenols Disease Research Fields Source Classification	Adenylate Cyclase Oxytocin Receptor
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs. Lysipressin activates Oxytocin receptors and *adenylate-cyclase*. Lysipressin adjusts blood pressure and heart rate. Lysipressin shows antinociceptive activity ^[3] .

HY-15371R

Forskolin (Standard) Coleonol (Standard); Colforsin (Standard); HL 362 (Standard)	Structural Classification Terpenoids Labiatae Diterpenoids Plants Pueraria montana (Lour.) Merr. Source Classification	Organoid Reference Standards Adenylate Cyclase FXR Autophagy PKC
Forskolin (Standard) is the analytical standard of Forskolin. This product is intended for research and analytical applications. Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR ^[3]. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-W010918R

Adenosine 5'-diphosphate (Standard) Adenosine diphosphate (Standard); ADP (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
Adenosine 5'-diphosphate (Standard) is the analytical standard of Adenosine 5'-diphosphate. This product is intended for research and analytical applications. Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors. In Vitro: Adenosine 5'-diphosphate consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells. Adenosine 5'-diphosphate is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.

HY-N7395A

Cyclic ADP-ribose ammonium 1 Publications Verification cADPR ammonium	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels ^[3].

HY-N10772

Albanin A	Flavonoids Morus nigra Linn. Plants Moraceae Other Flavonoids Source Classification	Calcium Channel Calmodulin Adenylate Cyclase
Albanin A, a flavonoid, suppresses glutamate release by decreasing *Ca ²⁺/calmodulin/adenylate* Cyclase 1 (AC1)** activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity .

HY-N0927

(-)-Isocorypalmine Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine	Alkaloids Structural Classification Monophenols other families Classification of Application Fields Other Diseases Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Dopamine Receptor
(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research .

HY-126055

Hadacidin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Adenylate Cyclase
Hadacidin is a competitive inhibitor of adenylate synthase. Hadacidin binds to the active site of adenylate synthase, competitively inhibiting L-aspartate binding. Hadacidin can be used in drug design, to help develop new inhibitors or activators to regulate adenylate synthase activity, and to play a role in the study of related diseases .

HY-P0004R

Lysipressin (Standard) Lysine vasopressin (Standard); [Lys8]-Vasopressin (Standard)	Structural Classification Monophenols Animals Phenols Source Classification	Reference Standards Adenylate Cyclase
Lysipressin (Standard) is the analytical standard of Lysipressin. This product is intended for research and analytical applications. Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-137934

Deacetylforskolin 7-Deacetylforskolin	Terpenoids Labiatae Diterpenoids Plants Pueraria montana (Lour.) Merr. Source Classification	Endogenous Metabolite
Deacetylforskolin is a deacetylated derivative of forskolin (HY-15371) that can be extracted from C. forskohlii. Deacetylforskolin activates rat adipocyte adenylyl cyclase (IC₅₀ = 20 µM), inhibits glucose transport in rat adipocyte plasma membranes and exhibits antihypertensive activity .

HY-Y0265R

Isatin (Standard) Indoline-2,3-dione (Standard)	Alkaloids Structural Classification other families Plants Indole Alkaloids Source Classification	Reference Standards Monoamine Oxidase Apoptosis
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system ^[3].

HY-N11141

(R)-Octopamine	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Adrenergic Receptor
(R)-Octopamine is a Gs-coupled receptor agonist. (R)-Octopamine binds to the orthosteric site of BmOAR2 and interacts with the Asp115, Ser202 and Tyr300 residues to activate the receptor, which couples to Gs protein and thereby stimulates adenylate cyclase activity .

HY-180649

Acetyl adenylate 5'-Acetylphosphoadenosine	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
Acetyl adenylate (5'-Acetylphosphoadenosine) is a nucleoside metabolite.

HY-W725644

L-2-Aminoadipate adenylate	Structural Classification Natural Products Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
L-2-Aminoadipate adenylate is a nucleoside metabolite.

HY-N18036

(3E,7E)-Homofarnesol	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source Classification	Others
(3E,7E)-Homofarnesol is a C₁₆ isoprenoid alcohol and non-natural substrate for squalene-hopene cyclases. (3E,7E)-Homofarnesol undergoes cyclization to form ambroxan .

Cat. No.	Product Name	Chemical Structure

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator ^[3] . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-W010918S2

Adenosine 5'-diphosphate-15N5 dilithium

Adenosine 5'-diphosphate- ¹⁵N₅ (Adenosine diphosphate- ¹⁵N₅ dilithium) dilithium is ¹⁵N labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-W010918S3

Adenosine 5'-diphosphate-13C5

Adenosine 5'-diphosphate- ¹³C₅ (Adenosine diphosphate- ¹³C₅) is the ¹³C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.

HY-16774S2

Vericiguat-d6
Vericiguat-d₆ (BAY1021189-d₆) is deuterium labeled Vericiguat. Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator ^[3] . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16774S

Vericiguat-d3 hydrochloride
Vericiguat-d3 (BAY1021189-d3) hydrochloride is a deuterated Vericiguat with tracer functionality. Vericiguat is an orally available stimulator of guanylate cyclase .

HY-14779S3

Riociguat-d3
Riociguat-d₃ (BAY 632521-d₃) is deuterium labeled Riociguat. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-14779S

Riociguat-13C,d6
Riociguat- ¹³C,d₆ is the ¹³C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-W759997

Reproterol-d3
Reproterol-d₃ is the deuterium labeled Reproterol (HY-135490). Reproterol is a dual acting β2-adrenoceptor agonist and PDE inhibitor. The theophylline constituent of Reproterol inhibits phosphodiesterase activity induced by adenylyl cyclase. Reproterol has the potential for asthma research .

Targets Recommended: Adenylate Cyclase Guanylate Cyclase Serpin PACAP Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure