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Cat. No.: HY-112270

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Glutaminyl Cyclase Inhibitor 2

Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor with an IC₅₀ of 1.23 μM.

For research use only. We do not sell to patients.

CAS No.: 1884546-29-5
Formula: C₁₉H₂₀FN₃
Molecular Weight:309.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Glutaminyl Cyclase Inhibitor 2 Chemical Structure

CAS No.: 1884546-29-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor with an IC₅₀ of 1.23 μM.

IC₅₀ & Target

IC50: 1.23 μM (Glutaminyl cyclase)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	IC₅₀	118 nM Compound: 5	Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells using H-Gln-AMC hydrobromide as substrate measured in presence of pGAPase by fluorometric assay Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells using H-Gln-AMC hydrobromide as substrate measured in presence of pGAPase by fluorometric assay	[PMID: 31411468]

In Vitro

Glutaminyl Cyclase Inhibitor 2 is compound 28^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1884546-29-5
Molecular Weight 309.38
Formula C₁₉H₂₀FN₃
SMILES

FC1=CC=C(C2=C(NCCCN3C=C(C)N=C3)C=CC=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li M, et al. Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease. J Med Chem. 2017 Aug 10;60(15):6664-6677. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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