Glutaminyl Cyclase Inhibitor 3
Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions.
For research use only. We do not sell to patients.
- CAS No.: 2092921-50-9
- Formula: C24H32N6O2S
- Molecular Weight:468.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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β-Amyloid (1-42), human
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HY-P1363B
β-Amyloid (1-42), human, HFIP-treated
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FPS-ZM1
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Glutaminyl Cyclase Inhibitor 1
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ARN2966
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HY-103241
Ro 90-7501
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Edonerpic maleate
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HY-112270
Glutaminyl Cyclase Inhibitor 2
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HY-P0128
β-Amyloid (25-35)
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HY-105252A
BF 227
Biological Activity
IC50: 4.5 nM (hGC)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
4.5 nM
Compound: 6
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Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells using H-Gln-AMC hydrobromide as substrate measured in presence of pGAPase by fluorometric assay
Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells using H-Gln-AMC hydrobromide as substrate measured in presence of pGAPase by fluorometric assay
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[PMID: 31411468] |
Chemical Information
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CAS No. 2092921-50-9
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Molecular Weight 468.61
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Formula C24H32N6O2S
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SMILES
COC1=C(OCCCCC2=CC(N)=NC=C2)C=CC(NC(NCCCN3C(C)=CN=C3)=S)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glutaminyl Cyclase Inhibitor 3 Related Classifications
HY-101282 Related Classifications
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