2092921-50-9
Chemical Structure
Glutaminyl Cyclase Inhibitor 3
- CAS No.: 2092921-50-9
- Formula:C24H32N6O2S
- Molecular Weight:468.61
IUPAC Name: 1-(4-(4-(2-aminopyridin-4-yl)butoxy)-3-methoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)thiourea
InChIKey: MXAZSKBTKUGBLI-UHFFFAOYSA-N
SMILES: COC1=C(OCCCCC2=CC(N)=NC=C2)C=CC(NC(NCCCN3C(C)=CN=C3)=S)=C1
Biological Activity: Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1].
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Glutaminyl Cyclase Inhibitor 3 | Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions. | |||||||||||||||||||||
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Keywords
