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Azeliragon (Synonyms: TTP488)

Cat. No.: HY-50682 Purity: 99.37%
Data Sheet SDS Handling Instructions

TTP488 is an antagonist at the Receptor for Advanced Glycation End products, is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD).

For research use only. We do not sell to patients.
Azeliragon Chemical Structure

Azeliragon Chemical Structure

CAS No. : 603148-36-3

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10 mM * 1 mL in DMSO $140 In-stock
5 mg $120 In-stock
10 mg $190 In-stock
50 mg $550 In-stock
100 mg $900 In-stock
200 mg $1500 In-stock
500 mg $2100 In-stock
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  • Biological Activity

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Description

TTP488 is an antagonist at the Receptor for Advanced Glycation End products, is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD). Target: RAGE in vitro: TTP488 is an orally active, centrally acting antagonist of RAGE-RAGE ligand interaction. Chronic oral dosing of TTP488 in AD transgenic mice led to a reduction of amyloid load in the brain, improves performance on behavioral testing and normalization of electrophysiological recordings from hippocampal slices.[1] in vivo: The small molecule RAGE antagonist, TTP488, is developed by Trans-Tech Pharma. The TTP488 or control peptide is administered i.p. daily at a dose of 100 mcg/d.[3] Successful use of the RAGE inhibitor TTP488 in Phase II testing has led to a Phase III clinical trial for AD patients.[2]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02916056 vTv Therapeutics Alzheimer's Disease December 2016 Phase 3
NCT02080364 vTv Therapeutics Alzheimer's Disease April 2015 Phase 3
NCT02916056 vTv Therapeutics Alzheimer's Disease December 2016 Phase 3
NCT02080364 vTv Therapeutics Alzheimer's Disease April 2015 Phase 3
NCT00287183 Pfizer Diabetic Nephropathy February 2006 Phase 2
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References
Molecular Weight

532.12

Formula

C₃₂H₃₈ClN₃O₂

CAS No.

603148-36-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Azeliragon
Cat. No.:
HY-50682
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