1. GPCR/G Protein
  2. Guanylate Cyclase
  3. BI 703704

BI 703704 

Cat. No.: HY-117962A
Handling Instructions

BI 703704 is a potent soluble guanylate cyclase (sGC) activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat.

For research use only. We do not sell to patients.

BI 703704 Chemical Structure

BI 703704 Chemical Structure

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Description

BI 703704 is a potent soluble guanylate cyclase (sGC) activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat[1].

In Vivo

BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) results in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content[1].
BI 703704 is effective in elevating renal cGMP levels in a dose-dependent manner and in slowing the progression of diabetic nephropathy in an oxidative stress milieu[1].

Animal Model: Fifty-eight male ZSF1 rats (12-13 weeks)[1]
Dosage: 0.3, 1, 3, or 10 mg/kg
Administration: Food intake; daily for 15 weeks
Result: Resulted in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content.
Molecular Weight

559.72

Formula

C₃₂H₃₇N₃O₄S

SMILES

CC1=CC(C2=CSC(N3C[[email protected]](CC4)[[email protected]@H](C(O)=O)[[email protected]]4C3)=N2)=C(OCC5=CC=C(C(N6CCCCC6)=O)C=C5C)C=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BI 703704BI703704BI-703704Guanylate CyclasediabeticnephropathyZSF1ratcGMPtype2diabetesoxidativestressmilieuInhibitorinhibitorinhibit

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BI 703704
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HY-117962A
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