1. GPCR/G Protein
  2. Guanylate Cyclase
  3. (Rac)-BI 703704

(Rac)-BI 703704 

Cat. No.: HY-117962
Handling Instructions

(Rac)-BI 703704 is a potent soluble guanylyl cyclase (sGC) activator. (Rac)-BI 703704 reduces progression of renal damage in the ZSF1 rat, and highlight the potential of sGC activation as an effective therapy for diabetic nephropathy.

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(Rac)-BI 703704 Chemical Structure

(Rac)-BI 703704 Chemical Structure

CAS No. : 1423067-48-4

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Description

(Rac)-BI 703704 is a potent soluble guanylyl cyclase (sGC) activator. (Rac)-BI 703704 reduces progression of renal damage in the ZSF1 rat, and highlight the potential of sGC activation as an effective therapy for diabetic nephropathy[1].

In Vivo

(Rac)-BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) inhibits the progression of diabetic nephropathy in the ZSF1 rat[1].

Animal Model: 12-13 weeks male ZSF1 obese rats[1]
Dosage: 0.3, 1, 3, or 10 mg/kg
Administration: Food intake; daily for 15 weeks
Result: Dose-dependent increased in renal cGMP levels; Dosedependent decreased in urinary protein excretion (UPE); Accompanied by a significant reduction in the incidence of glomerulosclerosis and interstitial lesions.
Molecular Weight

559.72

Formula

C₃₂H₃₇N₃O₄S

CAS No.

1423067-48-4

SMILES

O=C(C1C2CN(C3=NC(C4=CC(C)=CC=C4OCC5=CC=C(C(N6CCCCC6)=O)C=C5C)=CS3)CC1CC2)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(Rac)-BI 703704Guanylate CyclaseZSF1ratdiabeticnephropathycGMPeNOSInhibitorinhibitorinhibit

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