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EPAC 5376753 

Cat. No.: HY-111446
Handling Instructions

EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.

For research use only. We do not sell to patients.

EPAC 5376753 Chemical Structure

EPAC 5376753 Chemical Structure

CAS No. : 302826-61-5

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EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.

IC50 & Target

IC50: 4 µM (Epac)[1]

In Vitro

Epac is a key mediator of cAMP signaling. EPAC 5376753, the thiobarbituric acid modification of 5225554, has a greater ability to decrease the conformational changes of Epac necessary for its activation and to inhibit Epac signaling in cells. 5376753 selectively inhibits Epac-mediated migration in fibroblasts[1].

Molecular Weight









Room temperature in continental US; may vary elsewhere


Please store the product under the recommended conditions in the Certificate of Analysis.

Cell Assay

Swiss 3T3 cells are treated with EPAC 5376753 (1, 10, 25, 50, 75, 100 μM) or 1% dimethyl sulfoxide for 48 h. Cell viability is assessed using the CellTiter-Glo assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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