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EPAC 5376753 

Cat. No.: HY-111446
Handling Instructions

EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.

For research use only. We do not sell to patients.

EPAC 5376753 Chemical Structure

EPAC 5376753 Chemical Structure

CAS No. : 302826-61-5

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.

IC50 & Target

IC50: 4 µM (Epac)[1]

In Vitro

Epac is a key mediator of cAMP signaling. EPAC 5376753, the thiobarbituric acid modification of 5225554, has a greater ability to decrease the conformational changes of Epac necessary for its activation and to inhibit Epac signaling in cells. 5376753 selectively inhibits Epac-mediated migration in fibroblasts[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7232 mL 13.6162 mL 27.2324 mL
5 mM 0.5446 mL 2.7232 mL 5.4465 mL
10 mM 0.2723 mL 1.3616 mL 2.7232 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Swiss 3T3 cells are treated with EPAC 5376753 (1, 10, 25, 50, 75, 100 μM) or 1% dimethyl sulfoxide for 48 h. Cell viability is assessed using the CellTiter-Glo assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

367.21

Formula

C₁₅H₈Cl₂N₂O₃S

CAS No.

302826-61-5

SMILES

O=C(/C(C(N1)=O)=C/C2=CC=C(C3=CC=C(Cl)C=C3Cl)O2)NC1=S

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
EPAC 5376753
Cat. No.:
HY-111446
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EPAC 5376753

Cat. No.: HY-111446