1. GPCR/G Protein
  2. Guanylate Cyclase
  3. Praliciguat

Praliciguat (Synonyms: IW-1973)

Cat. No.: HY-109039
Handling Instructions

Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM.

For research use only. We do not sell to patients.

Praliciguat Chemical Structure

Praliciguat Chemical Structure

CAS No. : 1628730-49-3

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Description

Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM[1].

IC50 & Target

EC50: 197 nM (sGC)[1]

Clinical Trial
Molecular Weight

534.36

Formula

C₂₁H₁₄F₈N₆O₂

CAS No.

1628730-49-3

SMILES

FC1=C(C=CC=C1)CN2C(C3=NOC=C3)=CC(C4=NC=C(F)C(NCC(C(F)(F)F)(O)C(F)(F)F)=N4)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PraliciguatIW-1973IW1973IW 1973Guanylate CyclaseInhibitorinhibitorinhibit

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