CFM 1571 hydrochloride
Based on 1 Customer Validation
CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases.
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- Purity : 99.47%
- CAS No.: 1215548-30-3
- 화학식: C23H29ClN4O3
- 분자량:444.95
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
IC50 & Target
Chemical Information
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CAS No. 1215548-30-3
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Appearance Solid
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분자량 444.95
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화학식 C23H29ClN4O3
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Color White to off-white
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SMILES
O=C(C1=CC(OCCCN(C)C)=NN1CC2=CC=CC=C2)NC3=CC=C(C=C3)OC.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
In Vitro:
DMSO : 100 mg/mL (224.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Selwood DL, et al. Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J Med Chem. 2001;44(1):78-93. [Content Brief]
[2]. Evgenov OV, et al. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 2006;5(9):755-768. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2474 mL | 11.2372 mL | 22.4744 mL | 56.1861 mL |
| 5 mM | 0.4495 mL | 2.2474 mL | 4.4949 mL | 11.2372 mL | |
| 10 mM | 0.2247 mL | 1.1237 mL | 2.2474 mL | 5.6186 mL | |
| 15 mM | 0.1498 mL | 0.7491 mL | 1.4983 mL | 3.7457 mL | |
| 20 mM | 0.1124 mL | 0.5619 mL | 1.1237 mL | 2.8093 mL | |
| 25 mM | 0.0899 mL | 0.4495 mL | 0.8990 mL | 2.2474 mL | |
| 30 mM | 0.0749 mL | 0.3746 mL | 0.7491 mL | 1.8729 mL | |
| 40 mM | 0.0562 mL | 0.2809 mL | 0.5619 mL | 1.4047 mL | |
| 50 mM | 0.0449 mL | 0.2247 mL | 0.4495 mL | 1.1237 mL | |
| 60 mM | 0.0375 mL | 0.1873 mL | 0.3746 mL | 0.9364 mL | |
| 80 mM | 0.0281 mL | 0.1405 mL | 0.2809 mL | 0.7023 mL | |
| 100 mM | 0.0225 mL | 0.1124 mL | 0.2247 mL | 0.5619 mL |
CFM 1571 hydrochloride Related Classifications
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