CFM 1571 hydrochloride
Based on 1 Customer Validation
CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases.
For research use only. We do not sell to patients.
- Purity: 99.47%
- CAS No.: 1215548-30-3
- Formula: C23H29ClN4O3
- Molecular Weight:444.95
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 1215548-30-3
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Appearance Solid
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Molecular Weight 444.95
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Formula C23H29ClN4O3
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Color White to off-white
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SMILES
O=C(C1=CC(OCCCN(C)C)=NN1CC2=CC=CC=C2)NC3=CC=C(C=C3)OC.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (224.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Selwood DL, et al. Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J Med Chem. 2001;44(1):78-93. [Content Brief]
[2]. Evgenov OV, et al. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 2006;5(9):755-768. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2474 mL | 11.2372 mL | 22.4744 mL | 56.1861 mL |
| 5 mM | 0.4495 mL | 2.2474 mL | 4.4949 mL | 11.2372 mL | |
| 10 mM | 0.2247 mL | 1.1237 mL | 2.2474 mL | 5.6186 mL | |
| 15 mM | 0.1498 mL | 0.7491 mL | 1.4983 mL | 3.7457 mL | |
| 20 mM | 0.1124 mL | 0.5619 mL | 1.1237 mL | 2.8093 mL | |
| 25 mM | 0.0899 mL | 0.4495 mL | 0.8990 mL | 2.2474 mL | |
| 30 mM | 0.0749 mL | 0.3746 mL | 0.7491 mL | 1.8729 mL | |
| 40 mM | 0.0562 mL | 0.2809 mL | 0.5619 mL | 1.4047 mL | |
| 50 mM | 0.0449 mL | 0.2247 mL | 0.4495 mL | 1.1237 mL | |
| 60 mM | 0.0375 mL | 0.1873 mL | 0.3746 mL | 0.9364 mL | |
| 80 mM | 0.0281 mL | 0.1405 mL | 0.2809 mL | 0.7023 mL | |
| 100 mM | 0.0225 mL | 0.1124 mL | 0.2247 mL | 0.5619 mL |
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