CFM 1571 hydrochloride

Cat. No.: HY-107546 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC₅₀ and IC₅₀ of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases.

For research use only. We do not sell to patients.

CFM 1571 hydrochloride Chemical Structure

CAS No. : 1215548-30-3

Size	Price	Stock	Quantity
5 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 980	Get quote	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

sGC^[1]^[2]

Molecular Weight

444.95

Formula

C₂₃H₂₉ClN₄O₃

CAS No.

1215548-30-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(OCCCN(C)C)=NN1CC2=CC=CC=C2)NC3=CC=C(C=C3)OC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (224.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2474 mL	11.2372 mL	22.4744 mL
5 mM	0.4495 mL	2.2474 mL	4.4949 mL
10 mM	0.2247 mL	1.1237 mL	2.2474 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (275 KB) SDS (251 KB)

COA (255 KB) Elemental Analysis Report (113 KB)

Handling Instructions (2659 KB)

References

[1]. Selwood DL, et al. Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J Med Chem. 2001;44(1):78-93. [Content Brief]

[2]. Evgenov OV, et al. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 2006;5(9):755-768. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2474 mL	11.2372 mL	22.4744 mL	56.1861 mL
	5 mM	0.4495 mL	2.2474 mL	4.4949 mL	11.2372 mL
	10 mM	0.2247 mL	1.1237 mL	2.2474 mL	5.6186 mL
	15 mM	0.1498 mL	0.7491 mL	1.4983 mL	3.7457 mL
	20 mM	0.1124 mL	0.5619 mL	1.1237 mL	2.8093 mL
	25 mM	0.0899 mL	0.4495 mL	0.8990 mL	2.2474 mL
	30 mM	0.0749 mL	0.3746 mL	0.7491 mL	1.8729 mL
	40 mM	0.0562 mL	0.2809 mL	0.5619 mL	1.4047 mL
	50 mM	0.0449 mL	0.2247 mL	0.4495 mL	1.1237 mL
	60 mM	0.0375 mL	0.1873 mL	0.3746 mL	0.9364 mL
	80 mM	0.0281 mL	0.1405 mL	0.2809 mL	0.7023 mL
	100 mM	0.0225 mL	0.1124 mL	0.2247 mL	0.5619 mL