2. Anti-infection
  3. Bacterial
  4. Anti-virulence factor-IN-3

Anti-virulence factor-IN-3 (Compound 21) is a covalent β-aminosulfinyl type anthrax edema factor (EF) inhibitor, with a Ki value of 0.44 μM. Anti-virulence factor-IN-3 generates an active ethylene sulfinyl intermediate, which forms an irreversible covalent bond with the Lys residue at the active center of EF, permanently inhibiting the adenylate cyclase activity of EF. Anti-virulence factor-IN-3 effectively inhibits the cAMP production induced by EF, with an EC50 value of 0.15 μM. Anti-virulence factor-IN-3 can be used for research on anthrax Infection.

For research use only. We do not sell to patients.

Anti-virulence factor-IN-3

Anti-virulence factor-IN-3 Chemical Structure

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Anti-virulence factor-IN-3 Related Antibodies

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Description

Anti-virulence factor-IN-3 (Compound 21) is a covalent β-aminosulfinyl type anthrax edema factor (EF) inhibitor, with a Ki value of 0.44 μM. Anti-virulence factor-IN-3 generates an active ethylene sulfinyl intermediate, which forms an irreversible covalent bond with the Lys residue at the active center of EF, permanently inhibiting the adenylate cyclase activity of EF. Anti-virulence factor-IN-3 effectively inhibits the cAMP production induced by EF, with an EC50 value of 0.15 μM. Anti-virulence factor-IN-3 can be used for research on anthrax Infection[1].

Molecular Weight

563.73

Formula

C29H33N5O3S2
SMILES

CN(CCS(=O)(C1=CC=C(C=C1)C(N2CCC(CC2)C3=CSC4=C(N=CN=C34)N)=O)=O)CCC5=CC=CC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Anti-virulence factor-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-virulence factor-IN-3BacterialAnthrax edema factorEnzyme-activated substrate inhibitionCovalent inhibitorVirulence factorAdenylate cyclaseβ-aminosulfonecAMP inhibitionBacterial toxinInhibitorinhibitorinhibit

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