CCPA hemihydrate  (Synonyms: 2-Chloro-N6-cyclopentyladenosine hemihydrate)

CCPA (2-Chloro-N6-cyclopentyladenosine) hemihydrate a highly selective A1 adenosine receptors agonist with a K_i of 0.4 nM. CCPA hemihydrate inhibits adenylate cyclase with an IC₅₀ of 33 nM. CCPA hemihydrate exhibits anti-seizure and cardiacprotective activity. CCPA hemihydrate can be used for the research of seizure and myocardial infarction^[1][2][3].

CCPA hemihydrate potently binds to rat brain membrane A₁ adenosine receptors with a K_i of 0.4 nM, demonstrating high A₁ selectivity (K_i of 3900 nM for A₂)^[1].
CCPA hemihydrate acts as a full A₁ adenosine receptor agonist to inhibit rat fat cell membrane adenylate cyclase with an IC₅₀ of 33 nM, and shows an IC₅₀ of 3500 nM for A₂^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCPA (0.25-0.5 mg/kg; i,p,; single dose) hemihydrate increases the electroconvulsive threshold in a mouse model of seizures induced by maximal electroshock (MES)^[2].
CCPA (0.125 mg/kg; i.v.; 30 min before induction) hemihydrate reduces infarct size in a rabbit model of coronary artery occlusion-induced myocardial infarction^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

378.81

C₁₅H₂₀ClN₅O₄.1/2H₂O

1217443-91-8

ClC(N=C1NC2CCCC2)=NC3=C1N=CN3[C@H]4[C@H](O)[C@H](O)[C@@H](CO)O4.O.[0.5]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Czuczwar S J. 2-Chloro-N 6-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model A[J]. Pharmacological reports, 2005, 57(787): 787-794.  [Content Brief]

  [2]. Tsuchida A, et al. Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbits[J]. Cardiovascular research, 1993, 27(4): 652-656.  [Content Brief]

  [3]. Lohse MJ, et al. 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1988;337(6):687-689.  [Content Brief]