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Cat. No.: HY-183556

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NSC156565

NSC156565 is a Pycsar immune system inhibitor and phage infection potentiator. NSC156565 blocks PycTM cytotoxic effects via prevention of 3′,5′-cCMP-mediated activation or inhibition of activated effector membrane-perturbing activity. NSC156565 enables bacteriophage Bas34 to overcome Pycsar-mediated resistance, facilitating productive phage infection and replication.

For research use only. We do not sell to patients.

CAS No.: 71335-86-9
Formula: C₂₂H₁₇NO₄
Molecular Weight:359.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC156565 Chemical Structure

CAS No.: 71335-86-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

NSC156565 (11-111 μM; 1 h pretreatment) potently inhibits the Pycsar antiphage defense in Pycsar-expressing E. coli JW5503ΔtolC, enabling >10⁴-fold increased Bas34 phage replication and phage-induced bacterial lysis when used at 111 μM^[1].
NSC156565 (111 μM) does not inhibit cCMP production by the PycC cyclase in PycC-expressing E. coli MG1655^[1].
NSC156565 (11 μM; 200 min) blocks PycTM-induced cell death in Pycsar-expressing E. coli JW5503ΔtolC, rescuing growth inhibited by exogenous cCMP^[1].
NSC156565 (0.01-100 μM; 1 h pretreatment) inhibits the Pycsar antiphage defense in Pycsar-expressing E. coli JW5503ΔtolC in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 71335-86-9
Molecular Weight 359.37
Formula C₂₂H₁₇NO₄
SMILES

OC1=C2C(C3=C(C(C2=C(C=C1)NC4=CC=C(C=C4)CCO)=O)C=CC=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Addo MA, et al. Discovery of Small-Molecule Inhibitors of the Pycsar Antiphage Defense. ACS Chem Biol. 2026;21(5):1073-1082. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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