2. Metabolic Enzyme/Protease GPCR/G Protein TGF-beta/Smad Stem Cell/Wnt Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite Adenylate Cyclase PKA Calcium Channel
  4. Cerebellin

Cerebellin is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin can be used in neurological research.

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Cerebellin

Cerebellin Chemical Structure

CAS No. : 94071-26-8

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Cerebellin Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cerebellin is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin can be used in neurological research[1][2][3][4].

In Vitro

Cerebellin (1-100 nM; 10-30 min) potently stimulates the production of norepinephrine and cyclic adenosine monophosphate in rat adrenal medullary tissues via an adenylate cyclase/PKA-dependent pathway[1].
Cerebellin (1-100 nM; 90 min) inhibits glucose-stimulated insulin secretion from isolated rat islets[2].
Cerebellin (100 nM-1 μM; 1 hour) inhibits glucose/Exendin-4 (HY-13443)-stimulated insulin secretion in INS-1 cells[2].
Cerebellin (10 nM-1 μM; 5 min) reduces Forskolin (HY-15371)-induced cAMP accumulation in INS-1 cells in a concentration-dependent manner[2].
Cerebellin (100 nM) irreversibly reduces the intracellular free calcium concentration in INS-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cerebellin Related Antibodies
In Vivo

Cerebellin (1-1000 nM; intrarenal adrenal perfusion; continuous administration during sample collection) potently stimulates norepinephrine release from perfused rat adrenal glands via an adenylate cyclase/PKA-dependent pathway[1].
Cerebellin (0.5-1.5 nmol/100 g body weight; subcutaneous injection; single bolus) acts as an insulin inhibitor in healthy female Wistar rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (female, 8-12 weeks, 180-190 g)[2]
Dosage: 0.5 nmol/100 g body weight; 1.5 nmol/100 g body weight
Administration: s.c.; single bolus
Result: Significantly reduced plasma insulin concentration at both 60 and 120 minutes post-injection at 0.5 nmol/100 g body weight.
Significantly reduced plasma insulin concentration at 120 minutes post-injection at 1.5 nmol/100 g body weight.
Caused a moderate significant increase in plasma glucagon at 60 minutes post-injection at 1.5 nmol/100 g body weight.
Caused a moderate significant decrease in blood glucose at 60 minutes post-injection at 1.5 nmol/100 g body weight.
Molecular Weight

1632.78

Formula

C69H113N23O23
CAS No.
Sequence

Ser-Gly-Ser-Ala-Lys-Val-Ala-Phe-Ser-Ala-Ile-Arg-Ser-Thr-Asn-His
Sequence Shortening

SGSAKVAFSAIRSTNH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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Cerebellin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cerebellin94071-26-8Endogenous MetaboliteAdenylate CyclasePKACalcium ChannelAdenylyl cyclaseProtein kinase ACa2+ channelsCa channelsrat insulinoma cellsrat adrenomedullary tissueprecerebellin (Cbln1)cerebellar Purkinje cellscorticosteronenorepinephrinerat braindorsal cochlear nucleus cartwheel cellsadenylate cyclase/PKA-dependent signaling pathwayaldosteroneInhibitorinhibitorinhibit

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