CD38-IN-5
CD38-IN-5 (compound 1) is a CD38 inhibitor that selectively inhibits CD38 hydrolase with an IC50 of 4.0 μM. CD38-IN-5 does not inhibits CD38 cyclase. CD38-IN-5 is highly effective at promoting NK cell-mediated tumor toxicity. CD38-IN-5 increases NADH+ and IFNγ levels in activated PBMCs. CD38-IN-5 can be used for the study of cancer.
For research use only. We do not sell to patients.
- CAS No.: 314039-40-2
- Formula: C18H23N5
- Molecular Weight:309.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAL-33 | IC50 |
0.8 μM
Compound: 11c
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Inhibition of IL-6-induced STAT3 phosphorylation in human Cal33 cells assessed as nuclear translocation by Western blot analysis
Inhibition of IL-6-induced STAT3 phosphorylation in human Cal33 cells assessed as nuclear translocation by Western blot analysis
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[PMID: 25288188] |
| CAL-33 | IC50 |
1.2 μM
Compound: 11c
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Growth inhibition of human CAL33 cells
Growth inhibition of human CAL33 cells
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[PMID: 25288188] |
| CAL-33 | IC50 |
5.9 μM
Compound: 11c
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Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis
Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis
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[PMID: 25288188] |
| FaDu | IC50 |
1.9 μM
Compound: 11c
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Growth inhibition of human FADU cells
Growth inhibition of human FADU cells
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[PMID: 25288188] |
| L6 | CC50 |
10 μM
Compound: 5
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Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
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[PMID: 19364854] |
Chemical Information
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CAS No. 314039-40-2
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Molecular Weight 309.41
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Formula C18H23N5
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SMILES
CC1=CC(C)=CC2=C(C)N=C(N=C21)NC3=NC(C)=CC(C)(C)N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CD38-IN-5 Related Classifications
HY-164628 Related Classifications
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