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Cat. No.: HY-164628

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CD38-IN-5

CD38-IN-5 (compound 1) is a CD38 inhibitor that selectively inhibits CD38 hydrolase with an IC₅₀ of 4.0 μM. CD38-IN-5 does not inhibits CD38 cyclase. CD38-IN-5 is highly effective at promoting NK cell-mediated tumor toxicity. CD38-IN-5 increases NADH+ and IFNγ levels in activated PBMCs. CD38-IN-5 can be used for the study of cancer.

For research use only. We do not sell to patients.

CAS No.: 314039-40-2
Formula: C₁₈H₂₃N₅
Molecular Weight:309.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CD38-IN-5 Chemical Structure

CAS No.: 314039-40-2

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CAL-33	IC₅₀	0.8 μM Compound: 11c	Inhibition of IL-6-induced STAT3 phosphorylation in human Cal33 cells assessed as nuclear translocation by Western blot analysis Inhibition of IL-6-induced STAT3 phosphorylation in human Cal33 cells assessed as nuclear translocation by Western blot analysis	[PMID: 25288188]
CAL-33	IC₅₀	1.2 μM Compound: 11c	Growth inhibition of human CAL33 cells Growth inhibition of human CAL33 cells	[PMID: 25288188]
CAL-33	IC₅₀	5.9 μM Compound: 11c	Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis	[PMID: 25288188]
FaDu	IC₅₀	1.9 μM Compound: 11c	Growth inhibition of human FADU cells Growth inhibition of human FADU cells	[PMID: 25288188]
L6	CC₅₀	10 μM Compound: 5	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 19364854]

Chemical Information

CAS No. 314039-40-2
Molecular Weight 309.41
Formula C₁₈H₂₃N₅
SMILES

CC1=CC(C)=CC2=C(C)N=C(N=C21)NC3=NC(C)=CC(C)(C)N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Patrick M. Woster, et al. Selective targeting of cd38 activity as an immunostimulatory and antitumor strategy. WO2023039170A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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