1. GPCR/G Protein
  2. Guanylate Cyclase
  3. Ataciguat

Ataciguat (Synonyms: HMR-1766)

Cat. No.: HY-17500 Purity: 99.81%
Handling Instructions

Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects.

For research use only. We do not sell to patients.

Ataciguat Chemical Structure

Ataciguat Chemical Structure

CAS No. : 254877-67-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 216 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 216 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 170 In-stock
Estimated Time of Arrival: December 31
10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
25 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects[1][2][3].

IC50 & Target

soluble guanylate cyclase[1]

In Vitro

Ataciguat (1-100 μM) induces the relaxation in aortic rings or coronary rings[2].
Ataciguat (0.1-10 μM; 30 min) increases NO production in HUVEC cells[2].
Ataciguat (1 nM-100 μM) induces concentration-dependent relaxations in sphincter of Oddi (SO) rings pre-contracted by Carbachol[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

576.49

Formula

C₂₁H₁₉Cl₂N₃O₆S₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (173.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7346 mL 8.6732 mL 17.3464 mL
5 mM 0.3469 mL 1.7346 mL 3.4693 mL
10 mM 0.1735 mL 0.8673 mL 1.7346 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Ataciguat
Cat. No.:
HY-17500
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