Hadacidin sodium

Hadacidin (200 mg/kg; i.p.; administered in two equal doses at 45 min and 15 min before exercise) sodium increases IMP accumulation in fast-twitch skeletal muscle of Sprague-Dawley rats after treadmill exercise, but does not increase IMP in slow-twitch soleus muscle^[4].

Hadacidin sodium inhibits stem and root growth of Alaska pea plants grown in nutrient solution, and 16 days after foliar spraying, the average stem length decreases from 352 mm at 0 mg/L to 96 mm at 8000 mg/L^[2].
Hadacidin sodium inhibits the unfolding of the first trifoliolate leaf of pinto bean; when applied to the primary leaves of pinto bean, it is transported to the young trifoliolate leaves and inhibits their growth. In the bean leaf bioassay, the inhibition is counteracted by riboflavin, but not by glycine, whereas aspartic acid, asparagine, glutathione, and calcium pantothenate partially reverse it^[2].
Hadacidin sodium applied to tomato roots in nutrient solution completely stops root growth at 50 and 250 mg/L, and inhibits shoot growth by 40% at 50 mg/L and completely at 250 mg/L^[2].
Hadacidin (100 mg/kg; i.v.; 30 min before stimulation) sodium effectively blocks IMP (HY-108213) reamination in fast muscle of recovered rats; it also increases IMP accumulation in fast-twitch white gastrocnemius muscle, with no significant effect on IMP levels in fast-twitch red gastrocnemius muscle^[3].