Org 214444-0
Org 214444-0 is an orally active, nanomolar-potent and selective FSHR agonist, with EC50 values of 2.0 nM and 1.2 nM in human and rat (measured in CHO cells). Org 214444-0 activates human granulosa cells in vitro, supports rat follicular development and induces ovulation in vivo. Org 214444-0 can be used for the research of infertility.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 914093-78-0
- 分子式: C30H32BrF2N3O5S
- 分子量:664.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
体外実験
Org 214444-0 (1 h) stimulates cAMP production in CHO cells expressing human FSHR, with an EC50 of 5 nM[1].
Org 214444-0 (2 h) induces internalization of EGFP-tagged rat FSHR in U2OS cells, with an EC50 of 97 nM[1].
Org 214444-0 (1 nM-10 mM; 48 h) stimulates estradiol production in human granulosa cells, with an EC50 of approximately 8.3 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Orga rats (mature female)[1]
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Dosage:0.1 mg/kg; 0.25 mg/kg; 0.5 mg/kg; 1.0 mg/kg (s.c.); 1.0 mg/kg (p.o.)
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Administration:s.c.; twice daily on met-estrus and diestrus, once on proestrus morning; p.o.; every 4 hours
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Result:Caused a dose-dependent increase in the number of ovulated ova per rat.
化学情報
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CAS 番号 914093-78-0
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分子量 664.56
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分子式 C30H32BrF2N3O5S
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SMILES
N#CC1=C(C)NC(C[C@@H](CC2=O)CCC)=C2[C@@H]1C3=CC(OCC)=C(C(Br)=C3)OCC4=C(C=C(C(F)=C4)F)NS(C)(=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)