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Cat. No.: HY-182705

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Org 214444-0

Org 214444-0 is an orally active, nanomolar-potent and selective FSHR agonist, with EC₅₀ values of 2.0 nM and 1.2 nM in human and rat (measured in CHO cells). Org 214444-0 activates human granulosa cells in vitro, supports rat follicular development and induces ovulation in vivo. Org 214444-0 can be used for the research of infertility.

For research use only. We do not sell to patients.

CAS No.: 914093-78-0
Formula: C₃₀H₃₂BrF₂N₃O₅S
Molecular Weight:664.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Org 214444-0 Chemical Structure

CAS No.: 914093-78-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Estrogen Receptor/ERR Isoforms :

In Vitro

Org 214444-0 (1 h) stimulates cAMP production in CHO cells expressing human FSHR, with an EC₅₀ of 5 nM^[1].
Org 214444-0 (2 h) induces internalization of EGFP-tagged rat FSHR in U2OS cells, with an EC₅₀ of 97 nM^[1].
Org 214444-0 (1 nM-10 mM; 48 h) stimulates estradiol production in human granulosa cells, with an EC₅₀ of approximately 8.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Org 214444-0 (0.1-1.0 mg/kg; s.c./p.o.; twice daily / once every 4 hours; from estrous cycle to proestrus) dose-dependently supports the follicular phase and induces ovulation in female rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Orga rats (mature female)^[1]
Dosage:

0.1 mg/kg; 0.25 mg/kg; 0.5 mg/kg; 1.0 mg/kg (s.c.); 1.0 mg/kg (p.o.)
Administration:

s.c.; twice daily on met-estrus and diestrus, once on proestrus morning; p.o.; every 4 hours
Result:

Caused a dose-dependent increase in the number of ovulated ova per rat.

Chemical Information

CAS No. 914093-78-0
Molecular Weight 664.56
Formula C₃₀H₃₂BrF₂N₃O₅S
SMILES

N#CC1=C(C)NC(C[C@@H](CC2=O)CCC)=C2[C@@H]1C3=CC(OCC)=C(C(Br)=C3)OCC4=C(C=C(C(F)=C4)F)NS(C)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. van Koppen CJ, et al. Signaling of an allosteric, nanomolar potent, low molecular weight agonist for the follicle-stimulating hormone receptor. Biochem Pharmacol. 2013;85(8):1162-1170. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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