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製品番号: HY-182705

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Org 214444-0

Org 214444-0 is an orally active, nanomolar-potent and selective FSHR agonist, with EC₅₀ values of 2.0 nM and 1.2 nM in human and rat (measured in CHO cells). Org 214444-0 activates human granulosa cells in vitro, supports rat follicular development and induces ovulation in vivo. Org 214444-0 can be used for the research of infertility.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 914093-78-0
分子式: C₃₀H₃₂BrF₂N₃O₅S
分子量:664.56

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Org 214444-0 構造式

CAS 番号: 914093-78-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示 :

体外実験

Org 214444-0 (1 h) stimulates cAMP production in CHO cells expressing human FSHR, with an EC₅₀ of 5 nM^[1].
Org 214444-0 (2 h) induces internalization of EGFP-tagged rat FSHR in U2OS cells, with an EC₅₀ of 97 nM^[1].
Org 214444-0 (1 nM-10 mM; 48 h) stimulates estradiol production in human granulosa cells, with an EC₅₀ of approximately 8.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Org 214444-0 (0.1-1.0 mg/kg; s.c./p.o.; twice daily / once every 4 hours; from estrous cycle to proestrus) dose-dependently supports the follicular phase and induces ovulation in female rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Orga rats (mature female)^[1]
Dosage:

0.1 mg/kg; 0.25 mg/kg; 0.5 mg/kg; 1.0 mg/kg (s.c.); 1.0 mg/kg (p.o.)
Administration:

s.c.; twice daily on met-estrus and diestrus, once on proestrus morning; p.o.; every 4 hours
Result:

Caused a dose-dependent increase in the number of ovulated ova per rat.

化学情報

CAS 番号 914093-78-0
分子量 664.56
分子式 C₃₀H₃₂BrF₂N₃O₅S
SMILES

N#CC1=C(C)NC(C[C@@H](CC2=O)CCC)=C2[C@@H]1C3=CC(OCC)=C(C(Br)=C3)OCC4=C(C=C(C(F)=C4)F)NS(C)(=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. van Koppen CJ, et al. Signaling of an allosteric, nanomolar potent, low molecular weight agonist for the follicle-stimulating hormone receptor. Biochem Pharmacol. 2013;85(8):1162-1170. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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