Org 214444-0
Org 214444-0 is an orally active, nanomolar-potent and selective FSHR agonist, with EC50 values of 2.0 nM and 1.2 nM in human and rat (measured in CHO cells). Org 214444-0 activates human granulosa cells in vitro, supports rat follicular development and induces ovulation in vivo. Org 214444-0 can be used for the research of infertility.
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- CAS No.: 914093-78-0
- 화학식: C30H32BrF2N3O5S
- 분자량:664.56
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
제품 설명
In Vitro
Org 214444-0 (1 h) stimulates cAMP production in CHO cells expressing human FSHR, with an EC50 of 5 nM[1].
Org 214444-0 (2 h) induces internalization of EGFP-tagged rat FSHR in U2OS cells, with an EC50 of 97 nM[1].
Org 214444-0 (1 nM-10 mM; 48 h) stimulates estradiol production in human granulosa cells, with an EC50 of approximately 8.3 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Orga rats (mature female)[1]
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Dosage:0.1 mg/kg; 0.25 mg/kg; 0.5 mg/kg; 1.0 mg/kg (s.c.); 1.0 mg/kg (p.o.)
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Administration:s.c.; twice daily on met-estrus and diestrus, once on proestrus morning; p.o.; every 4 hours
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Result:Caused a dose-dependent increase in the number of ovulated ova per rat.
Chemical Information
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CAS No. 914093-78-0
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분자량 664.56
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화학식 C30H32BrF2N3O5S
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SMILES
N#CC1=C(C)NC(C[C@@H](CC2=O)CCC)=C2[C@@H]1C3=CC(OCC)=C(C(Br)=C3)OCC4=C(C=C(C(F)=C4)F)NS(C)(=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)