2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Org 214444-0

Org 214444-0 is an orally active, nanomolar-potent and selective FSHR agonist, with EC50 values of 2.0 nM and 1.2 nM in human and rat (measured in CHO cells). Org 214444-0 activates human granulosa cells in vitro, supports rat follicular development and induces ovulation in vivo. Org 214444-0 can be used for the research of infertility.

For research use only. We do not sell to patients.

Org 214444-0

Org 214444-0 Chemical Structure

CAS No. : 914093-78-0

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Org 214444-0 Related Antibodies

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Description

Org 214444-0 is an orally active, nanomolar-potent and selective FSHR agonist, with EC50 values of 2.0 nM and 1.2 nM in human and rat (measured in CHO cells). Org 214444-0 activates human granulosa cells in vitro, supports rat follicular development and induces ovulation in vivo. Org 214444-0 can be used for the research of infertility[1].

In Vitro

Org 214444-0 (1 h) stimulates cAMP production in CHO cells expressing human FSHR, with an EC50 of 5 nM[1].
Org 214444-0 (2 h) induces internalization of EGFP-tagged rat FSHR in U2OS cells, with an EC50 of 97 nM[1].
Org 214444-0 (1 nM-10 mM; 48 h) stimulates estradiol production in human granulosa cells, with an EC50 of approximately 8.3 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Org 214444-0 Related Antibodies
In Vivo

Org 214444-0 (0.1-1.0 mg/kg; s.c./p.o.; twice daily / once every 4 hours; from estrous cycle to proestrus) dose-dependently supports the follicular phase and induces ovulation in female rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Orga rats (mature female)[1]
Dosage: 0.1 mg/kg; 0.25 mg/kg; 0.5 mg/kg; 1.0 mg/kg (s.c.); 1.0 mg/kg (p.o.)
Administration: s.c.; twice daily on met-estrus and diestrus, once on proestrus morning; p.o.; every 4 hours
Result: Caused a dose-dependent increase in the number of ovulated ova per rat.
Molecular Weight

664.56

Formula

C30H32BrF2N3O5S
CAS No.
SMILES

N#CC1=C(C)NC(C[C@@H](CC2=O)CCC)=C2[C@@H]1C3=CC(OCC)=C(C(Br)=C3)OCC4=C(C=C(C(F)=C4)F)NS(C)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Org 214444-0 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Org 214444-0914093-78-0Estrogen Receptor/ERRmature female ratsFSHRhuman granulosa cellscAMPCHO cellsLHRTSHRphospholipase CU2OS cellsadenylyl cyclaseInhibitorinhibitorinhibit

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