Adenosine 3'-phosphate 5'-phosphosulfate triethylamine 

Adenosine 3'-phosphate 5'-phosphosulfate triethylamine, an adenine nucleotide derivative, is a selective P2Y1 antagonist with no effect on P2Y2, P2Y4, or P2Y6 receptors. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine can competitive inhibit ADP-induced platelet aggregation, as well as the ability of ADP to cause shape change and increases in Ca²⁺ in platelets, but had no effect on the inhibition of stimulated adenylate cyclase by ADP. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group^[1][2][3].

Adenosine 3'-phosphate 5'-phosphosulfate (10-100 μM) triethylamine inhibits ADP-induced aggregation, shape change, and intracellular Ca²⁺ elevation in human platelets^[3].
Adenosine 3'-phosphate 5'-phosphosulfate (100 μM) triethylamine induces transient relaxation in the Carbamoylcholine chloride (HY-B1208)-preconstricted rat duodenum with no effect on the contraction of the vas deferens and bladder in male albino rats and BALB/c mice^[3].
Adenosine 3'-phosphate 5'-phosphosulfate triethylamine is degraded on the surface of the rat vas deferens with a T_1/2 of 14.7 minutes, and the main degradation products is adenosine 3'-phosphate and 5'-phosphate^[3].
Adenosine 3'-phosphate 5'-phosphosulfate triethylamine is a high-energy sulfate donor for sulfating secretory macromolecules in the Golgi apparatus^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₁₆H₃₀N₆O₁₃P₂S

936827-87-1

CCN(CC)CC.O[C@H]1[C@](O[C@@H]([C@H]1OP(O)(O)=O)COP(OS(=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2.[x]

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• [1]. Prather B, et, al. Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays. Anal Biochem. 2012 Apr 1;423(1):86-92.  [Content Brief]

  [2]. Ryan P. Modified indole alkaloids for therapeutic uses. WO2022133314.

  [3]. Lüders F, et al. Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila. EMBO J. 2003 Jul 15;22(14):3635-44.  [Content Brief]

  [4]. Park H S, et al. Effects of adenosine 3′‐phosphate 5′‐phosphosulfate on P2 receptors in platelets and smooth muscle preparations[J]. Drug development research, 1998, 45(2): 67-73.