936827-87-1
Chemical Structure
Adenosine 3'-phosphate 5'-phosphosulfate triethylamine
- CAS No.: 936827-87-1
- Formula:C16H30N6O13P2S
- Molecular Weight:N/A
SMILES: CCN(CC)CC.O[C@H]1[C@](O[C@@H]([C@H]1OP(O)(O)=O)COP(OS(=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2.[x]
Biological Activity: Adenosine 3'-phosphate 5'-phosphosulfate triethylamine, an adenine nucleotide derivative, is a selective P2Y1 antagonist with no effect on P2Y2, P2Y4, or P2Y6 receptors. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine can competitive inhibit ADP-induced platelet aggregation, as well as the ability of ADP to cause shape change and increases in Ca2+ in platelets, but had no effect on the inhibition of stimulated adenylate cyclase by ADP. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group[1][2][3].
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Adenosine 3'-phosphate 5'-phosphosulfate triethylamine | Adenosine 3'-phosphate 5'-phosphosulfate triethylamine, an adenine nucleotide derivative, is a selective P2Y1 antagonist with no effect on P2Y2, P2Y4, or P2Y6 receptors. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine can competitive inhibit ADP-induced platelet aggregation, as well as the ability of ADP to cause shape change and increases in Ca2+ in platelets, but had no effect on the inhibition of stimulated adenylate cyclase by ADP. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group. | |||||||||||||||||||||
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- [1]. Prather B, et, al. Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays. Anal Biochem. 2012 Apr 1;423(1):86-92. [Content Brief]
- [2]. Ryan P. Modified indole alkaloids for therapeutic uses. WO2022133314.
- [3]. Lüders F, et al. Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila. EMBO J. 2003 Jul 15;22(14):3635-44. [Content Brief]
