Small Cardioactive Peptide B (SCPB)

Name: Small Cardioactive Peptide B (SCPB)
Brand: MedChemExpress
SKU: HY-P1495
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1495 Purity: 98.10%: FAQs
Data Sheet SDS COA Handling Instructions

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Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC₅₀s of 0.1 and 1.0 μM, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Small Cardioactive Peptide B (SCPB) Chemical Structure

CAS No. : 84746-43-0

Size	Price	Stock	Quantity
1 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

IC₅₀ & Target

EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues)^[1]

In Vitro

Small cardioactive peptide B (SCP_B) is a neurally active peptide endogenous to Aplysia. Small cardioactive peptide B (SCP_B) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCP_B) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCP_B) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCP_B) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCP_B) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC₅₀ values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCP_B) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC₅₀ value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCP_B)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCP_B) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC₅₀ of 0.1 and 1.0μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1141.41

Formula

C₅₂H₈₀N₁₄O₁₁S₂

CAS No.

84746-43-0

Appearance

Solid

Color

White to off-white

Sequence

Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH2

Sequence Shortening

MNYLAFPRM-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (43.81 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8761 mL	4.3805 mL	8.7611 mL
5 mM	0.1752 mL	0.8761 mL	1.7522 mL
10 mM	0.0876 mL	0.4381 mL	0.8761 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.10%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (255 KB) LCMS (258 KB) Elemental Analysis Report (115 KB)

Handling Instructions (2659 KB)

References

[1]. Cawthorpe DR, et al. The effects of small cardioactive peptide B on the isolated heart and gill of Aplysia californica. Can J Physiol Pharmacol. 1985 Aug;63(8):918-24. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.8761 mL	4.3805 mL	8.7611 mL	21.9027 mL
	5 mM	0.1752 mL	0.8761 mL	1.7522 mL	4.3805 mL
	10 mM	0.0876 mL	0.4381 mL	0.8761 mL	2.1903 mL
	15 mM	0.0584 mL	0.2920 mL	0.5841 mL	1.4602 mL
	20 mM	0.0438 mL	0.2190 mL	0.4381 mL	1.0951 mL
	25 mM	0.0350 mL	0.1752 mL	0.3504 mL	0.8761 mL
	30 mM	0.0292 mL	0.1460 mL	0.2920 mL	0.7301 mL
	40 mM	0.0219 mL	0.1095 mL	0.2190 mL	0.5476 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.