Small Cardioactive Peptide B (SCPB)
Based on 1 Customer Validation
Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.69%
- CAS No.: 84746-43-0
- Formula: C52H80N14O11S2
- Molecular Weight:1141.41
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues)[1]
Small cardioactive peptide B (SCPB) is a neurally active peptide endogenous to Aplysia. Small cardioactive peptide B (SCPB) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCPB) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCPB) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCPB) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCPB) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCPB) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCPB)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCPB) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC50 of 0.1 and 1.0μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 84746-43-0
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Appearance Solid
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Molecular Weight 1141.41
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Formula C52H80N14O11S2
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Color White to off-white
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Sequence
Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH2
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Sequence Shortening
MNYLAFPRM-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
H2O : 50 mg/mL (43.81 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8761 mL | 4.3805 mL | 8.7611 mL | 21.9027 mL |
| 5 mM | 0.1752 mL | 0.8761 mL | 1.7522 mL | 4.3805 mL | |
| 10 mM | 0.0876 mL | 0.4381 mL | 0.8761 mL | 2.1903 mL | |
| 15 mM | 0.0584 mL | 0.2920 mL | 0.5841 mL | 1.4602 mL | |
| 20 mM | 0.0438 mL | 0.2190 mL | 0.4381 mL | 1.0951 mL | |
| 25 mM | 0.0350 mL | 0.1752 mL | 0.3504 mL | 0.8761 mL | |
| 30 mM | 0.0292 mL | 0.1460 mL | 0.2920 mL | 0.7301 mL | |
| 40 mM | 0.0219 mL | 0.1095 mL | 0.2190 mL | 0.5476 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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