(-)-Isocorypalmine
Based on 1 Customer Validation
(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 483-34-1
- Formula: C20H23NO4
- Molecular Weight:341.40
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Dopamine Receptor Isoforms
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Biological Activity
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D1 Receptor |
D5 Receptor |
D2 Receptor |
D3 Receptor |
D4 Receptor |
(-)-Isocorypalmine exhibits a D1 receptor expression-dependent agonistic effect on human dopamine D1 receptors. In HEK293 cells with high and moderate D1 receptor expression, the EC50 values are 39 nM and 263 nM, respectively, while no agonistic effect is observed in cells with low D1 receptor expression. For the D5 receptor, (-)-Isocorypalmine has an EC50 of 20 nM and a Ki of 9.5 nM; its Ki values for D2, D3, and D4 receptors are 41.8 nM, 37.3 nM, and 77.4 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
(-)-Isocorypalmine (1-10 mg/kg; i.p.; single dose) dose-dependently reduces acute cocaine-induced locomotor hyperactivity in male CD-1 mice, with complete inhibition at 10 mg/kg[1].
(-)-Isocorypalmine (10 mg/kg; i.p.; once daily; 5 days) reduces acute cocaine-induced hyperlocomotion and blocks the development of repeated cocaine-induced locomotor sensitization in male CD-1 mice[1].
(-)-Isocorypalmine (10 mg/kg; i.p.; once daily; 6 days) blocks the acquisition of cocaine-induced conditioned place preference in male CD-1 mice without inducing preference or aversion itself[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 (8-week-old male, initial weight 25-30 g)[1]
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Dosage:1 mg/kg; 3 mg/kg; 10 mg/kg
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Administration:i.p.; single dose
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Result:Dose-dependently reduced acute cocaine-induced total, ambulatory, and non-ambulatory repetitive locomotor hyperactivity.
Significantly decreased cocaine-induced hyperactivity at 3 mg/kg and 10 mg/kg compared to vehicle-pretreated, cocaine-challenged mice.
Prevented significant cocaine-induced hyperactivity at 10 mg/kg relative to saline controls.
Had no effect on locomotor activity in mice treated with saline instead of cocaine.
Significantly reduced cocaine-induced hyperlocomotion with 30-minute pretreatment at 10 mg/kg, indicating inhibitory effect is independent of short-term locomotor sedation.
Chemical Information
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CAS No. 483-34-1
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Appearance Solid
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Molecular Weight 341.40
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Formula C20H23NO4
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Color White to off-white
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SMILES
OC(C=C1[C@@]2([H])N3CC4=C(C=CC(OC)=C4OC)C2)=C(C=C1CC3)OC
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Synonyms
Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 6.67 mg/mL (19.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9291 mL | 14.6456 mL | 29.2912 mL | 73.2279 mL |
| 5 mM | 0.5858 mL | 2.9291 mL | 5.8582 mL | 14.6456 mL | |
| 10 mM | 0.2929 mL | 1.4646 mL | 2.9291 mL | 7.3228 mL | |
| 15 mM | 0.1953 mL | 0.9764 mL | 1.9527 mL | 4.8819 mL |
(-)-Isocorypalmine Related Classifications
HY-N0927 Related Classifications
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