Vericiguat-d6
Vericiguat-d6 (BAY1021189-d6) is deuterium labeled Vericiguat. Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
For research use only. We do not sell to patients.
- Formula: C19H10D6F2N8O2
- Molecular Weight:432.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 1350653-20-1
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Molecular Weight 432.42
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Formula C19H10D6F2N8O2
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SMILES
O=C(OC)NC1=C(N)N=C(C2=NN(C([2H])([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C3F)C4=NC=C(F)C=C42)N=C1N
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Synonyms
BAY1021189-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Follmann M, et al. Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure. J Med Chem. 2017 Jun 22;60(12):5146-5161. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Vericiguat-d6 Related Classifications
HY-16774S2 Related Classifications
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