1. GPCR/G Protein
  2. Guanylate Cyclase
  3. BAY 41-8543

BAY 41-8543 is an orally active, nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research.

For research use only. We do not sell to patients.

BAY 41-8543 Chemical Structure

BAY 41-8543 Chemical Structure

CAS No. : 256498-66-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMF
ready for reconstitution
USD 127 In-stock
Solution
10 mM * 1 mL in DMF USD 127 In-stock
Solid
1 mg USD 62 In-stock
5 mg USD 115 In-stock
10 mg USD 220 In-stock
25 mg USD 462 In-stock
50 mg USD 770 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BAY 41-8543 is an orally active, nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research[1].

In Vivo

BAY 41-8543 (10-100 μg/kg; IV) produces small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output[1].
BAY 41-8543 (0.003, 0.01, 0.03, 0.1, and 0.3 mg/kg; iv) produces a dose-dependent and long-lasting decrease in blood pressure in anaesthetized rats. The blood pressure lowering effect of BAY 41-8543 lasts longer than the observation period of 30 min. BAY 41-8543 (0.1, 0.3 and 1.0 mg kg; oral) has maximal blood pressure lowering effects. The blood pressure lowering effects of the highest doses of BAY41-8543 lasts longer than the observation period of 120 min[2].
BAY 41-8543 (3 mg/kg; p.o.; twice daily; for 5 weeks) completely prevents the development of the increase in systolic blood pressure in 18-week-old renin transgenic rats (TGR(mRen2)27) on L-NAME treatment. BAY 41-8543 dramatically increases survival[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats weighing 325-450 g[1]
Dosage: 10, 30, and 100 μg/kg
Administration: IV
Result: Produced small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output.
Molecular Weight

420.44

Formula

C21H21FN8O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC(N)=C1N5CCOCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 16.67 mg/mL (39.65 mM; Need ultrasonic)

Ethanol : 1 mg/mL (2.38 mM; ultrasonic and warming and heat to 70°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3785 mL 11.8923 mL 23.7846 mL
5 mM 0.4757 mL 2.3785 mL 4.7569 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMF 1 mM 2.3785 mL 11.8923 mL 23.7846 mL 59.4615 mL
DMF 5 mM 0.4757 mL 2.3785 mL 4.7569 mL 11.8923 mL
10 mM 0.2378 mL 1.1892 mL 2.3785 mL 5.9462 mL
15 mM 0.1586 mL 0.7928 mL 1.5856 mL 3.9641 mL
20 mM 0.1189 mL 0.5946 mL 1.1892 mL 2.9731 mL
25 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3785 mL
30 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
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BAY 41-8543 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
BAY 41-8543
Cat. No.:
HY-W062836
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