GNAS Antibody (YA7045)
(Synonyms: Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody)GNAS Antibody (YA7045) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GNAS.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:2000 | 1:100 |
Product Details
GNAS Antibody (YA7045) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GNAS.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 44 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 46 kDa
Recombinant protein within human GNAS aa 2-251.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GNAS is a Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. Functions downstream of beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2[1][2][3][4][5][6].
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Subcellular Localization
Cell membrane
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Isoforms & Post-Translational Modification
P63092 has 8 isomers: P63092-1: 45665 Da (predicted); P63092-2: 44266 Da (predicted); P63092-3: 44179 Da (predicted); Q5JWF2-1: 111025 Da (predicted); Q5JWF2-2: 109626 Da (predicted); Q5JWF2-3: 77643 Da (predicted); O95467-1: 28029 Da (predicted); P63092-4: 45752 Da (predicted).
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Subunit
Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma
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SwissProt ID
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Synonyms
Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody
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