m,p-Dimethyl PPE
m,p-Dimethyl PPE is a D4 dopamine receptor ligand. m,p-Dimethyl PPE promotes GDP/GTP exchange of the G protein α-subunit, dissociates the receptor-G protein complex, stabilizes the low-affinity receptor state, and inhibits adenylate cyclase activity. m,p-Dimethyl PPE inhibits Forskolin (HY-15371)-induced melatonin synthesis in retinal photoreceptor cells and reduces the efficacy of full agonists when used in combination. m,p-Dimethyl PPE can be used in studies related to attention-deficit hyperactivity disorder.
For research use only. We do not sell to patients.
- CAS No.: 219704-16-2
- Formula: C16H26ClN
- Molecular Weight:267.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
m,p-Dimethyl PPE (Compound 1) binds to bovine retinal D2-like dopamine receptors with biphasic affinities, with a high-affinity Ki of 27 nM and a low-affinity Ki of 7600 nM[1].
m,p-Dimethyl PPE interacts with bovine retinal D4R in a G protein-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 219704-16-2
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Molecular Weight 267.84
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Formula C16H26ClN
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SMILES
CCCN(CCC1)CC1C2=CC=C(C)C(C)=C2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
m,p-Dimethyl PPE Related Classifications
HY-W686762 Related Classifications
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