Ap4dT tetraammonium

Cat. No.: HY-168345 Purity: 99.88%: Data Sheet
COA

SDS
Handling Instructions
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Ap4dT is an inhibitor for human adenylate kinase isozyme 1 (hAK1), that inhibits the ATP and ADP synthesis with IC₅₀s of 42 μM and 38 μM.

For research use only. We do not sell to patients.

Ap4dT tetraammonium Chemical Structure

CAS No. : 1146545-74-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Ap4dT is an inhibitor for human adenylate kinase isozyme 1 (hAK1), that inhibits the ATP and ADP synthesis with IC₅₀s of 42 μM and 38 μM^[1].

Molecular Weight

879.50

Formula

C₂₀H₄₁N₁₁O₂₀P₄

CAS No.

1146545-74-5

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(OP(OC[C@@H](O2)[C@@H](O)C[C@@H]2N3C(NC(C(C)=C3)=O)=O)(O)=O)(O)=O)(O)=O)(O)=O)O[C@H]1N4C5=NC=NC(N)=C5N=C4.N.N.N.N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (113.70 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1370 mL	5.6850 mL	11.3701 mL
5 mM	0.2274 mL	1.1370 mL	2.2740 mL
10 mM	0.1137 mL	0.5685 mL	1.1370 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.88%

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Data Sheet (270 KB) SDS (252 KB)

COA (251 KB) HNMR (345 KB) RP-HPLC (239 KB) MS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Kozakiewicz-Piekarz A, et al., Synthesis, kinetic studies, and QSAR of dinucleoside polyphosphate derivatives as human AK1 inhibitors. Bioorg Chem. 2024 Jul;148:107432. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.1370 mL	5.6850 mL	11.3701 mL	28.4252 mL
	5 mM	0.2274 mL	1.1370 mL	2.2740 mL	5.6850 mL
	10 mM	0.1137 mL	0.5685 mL	1.1370 mL	2.8425 mL
	15 mM	0.0758 mL	0.3790 mL	0.7580 mL	1.8950 mL
	20 mM	0.0569 mL	0.2843 mL	0.5685 mL	1.4213 mL
	25 mM	0.0455 mL	0.2274 mL	0.4548 mL	1.1370 mL
	30 mM	0.0379 mL	0.1895 mL	0.3790 mL	0.9475 mL
	40 mM	0.0284 mL	0.1421 mL	0.2843 mL	0.7106 mL
	50 mM	0.0227 mL	0.1137 mL	0.2274 mL	0.5685 mL
	60 mM	0.0190 mL	0.0948 mL	0.1895 mL	0.4738 mL
	80 mM	0.0142 mL	0.0711 mL	0.1421 mL	0.3553 mL
	100 mM	0.0114 mL	0.0569 mL	0.1137 mL	0.2843 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.