1. GPCR/G Protein
    Neuronal Signaling
  2. Somatostatin Receptor
    Adenylate Cyclase
  3. Angiopeptin TFA

Angiopeptin TFA 

Cat. No.: HY-P2090A Purity: 99.16%
Handling Instructions

Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibit adenylate cyclase or stimulate extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiopeptin TFA Chemical Structure

Angiopeptin TFA Chemical Structure

CAS No. : 2478421-60-0

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5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 400 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibit adenylate cyclase or stimulate extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research[1][2].

IC50 & Target

IC50: 0.26 nM (sst2) and 6.92 nM (sst5)[1][2]

In Vitro

Angiopeptin (0.1 nM- 10 μM; for 1 h) TFA acts as a partial agonist (pEC50=6.57) with a maximum response of 423% at 3 μM on the release of tritium on CHO hsst2 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Angiopeptin (20 and 50μg/kg; i.h.) TFA significantly inhibits neointimal formation[1].
Angiopeptin (20 μg/kg; per day) TFA significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1326.39

Formula

C₅₈H₇₃F₆N₁₁O₁₄S₂

CAS No.
Sequence Shortening

{Nal}CYWKVCT-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (7.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7539 mL 3.7696 mL 7.5393 mL
5 mM 0.1508 mL 0.7539 mL 1.5079 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Angiopeptin TFA
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HY-P2090A
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