AK2 Antibody (YA2691)(PBS only)

Cat. No.: HY-P82946A: Data Sheet User Guide for Antibodies
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AK2 Antibody (YA2691) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AK2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

AK2 Antibody (YA2691) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AK2.

Host

Rabbit

Molecular Weight

Predicted band size: 26 kDa;

Observed band size: 26 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P54819

Gene ID

204 [NCBI]

Immunogen

A synthetic peptide of human AK2 aa171-184.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:5000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:500
IP IP: Immunoprecipitation	1:10-1:100

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis

Subcellular Localization：Mitochondrion intermembrane space

Expression：
Tissue_specificity:Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level)

Isoforms & Post-Translational Modification：P54819 has 6 isomers: P54819-1: 26478 Da (predicted); P54819-2: 25615 Da (predicted); P54819-3: 22265 Da (predicted); P54819-4: 14709 Da (predicted); P54819-5: 24648 Da (predicted); P54819-6: 21636 Da (predicted).

Subunit：Monomer

Research Field

Cell Biology

Synonyms

adenylate kinase 2; ADK2; AK 2

Documentation

User Guide for Antibodies (1077 KB)