2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. SKF-82958

SKF-82958  (Synonyms: (±)-SKF-82958; Chloro-APB)

Cat. No.: HY-10435
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SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (SKF-82958 hydrobromide) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

SKF-82958 Chemical Structure

SKF-82958 Chemical Structure

CAS No. : 80751-65-1

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SKF-82958 Related Antibodies

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1 Publications Citing Use of MCE SKF-82958

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Description

SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM)[1].

In Vivo

SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate[2].
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[3]
Dosage: 0.5-2.0 mg/kg
Administration: I.p
Result: Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
Molecular Weight

329.82

Formula

C19H20ClNO2
CAS No.
SMILES

OC1=C(O)C=C2C(C3=CC=CC=C3)CN(CC=C)CCC2=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SKF-82958 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF-8295880751-65-1(±)-SKF-82958 Chloro-APBSKF82958SKF 82958Dopamine ReceptorjawmovementsdiscriminativestimulusantiparkinsonianInhibitorinhibitorinhibit

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