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Results for "

antihypertensives

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5-HT Receptor (16) Adenosine Receptor (2) Adenylate Cyclase (4) Adrenergic Receptor (94) Akt (8) Amino Acid Derivatives (3) AMPK (2) Androgen Receptor (2) Angiotensin Receptor (37) Angiotensin-converting Enzyme (ACE) (61) Anion Exchangers (1) Antibiotic (4) AP-1 (2) Apelin Receptor (APJ) (2) Apoptosis (44) Asialoglycoprotein Receptor (ASGPR) (1) Autophagy (30) Bacterial (19) Biochemical Assay Reagents (3) Bradykinin Receptor (1) Calcium Channel (62) Carbonic Anhydrase (11) Carboxylesterase (CES) (2) Caspase (4) Chloride Channel (1) Cholinesterase (ChE) (5) COMT (1) COX (4) Cytochrome P450 (1) DNA/RNA Synthesis (3) Dopamine Receptor (7) Dopamine β-hydroxylase (1) Drug Derivative (15) Drug Intermediate (2) Drug Isomer (1) Drug Metabolite (16) Endogenous Metabolite (33) Endothelin Receptor (6) Environmental Pollutants (1) Epoxide Hydrolase (2) Estrogen Receptor/ERR (1) Fluorescent Dye (1) FOXO (1) Fungal (3) FXR (3) GABA Receptor (1) GCGR (2) Glycosidase (1) GSK-3 (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (2) Histone Demethylase (1) HMG-CoA Reductase (HMGCR) (1) Imidazoline Receptor (8) Influenza Virus (1) Interleukin Related (8) Isotope-Labeled Compounds (43) JNK (2) Lipoxygenase (1) mAChR (3) MAPKAPK2 (MK2) (1) MEK (1) Mineralocorticoid Receptor (2) MMP (2) Monoamine Oxidase (4) Monocarboxylate Transporter (2) Na+/K+ ATPase (2) nAChR (8) Neprilysin (14) Neuropeptide Y Receptor (1) NF-κB (13) NKCC (4) NO Synthase (11) NOD-like Receptor (NLR) (2) Nucleoside Antimetabolite/Analog (59) Opioid Receptor (1) Organoid (2) Orphan GPCR (1) P-glycoprotein (1) p38 MAPK (6) p62 (2) Parasite (9) Phosphatase (2) Phosphodiesterase (PDE) (2) Phosphoramidites (5) PI3K (8) PKC (4) Platelet-activating Factor Receptor (PAFR) (2) Potassium Channel (23) PPAR (2) Prostaglandin Receptor (1) PTHR (1) Reactive Oxygen Species (ROS) (20) Reference Standards (93) Renin (9) ROCK (2) RSV (2) SARS-CoV (1) Ser/Thr Protease (1) SGK (3) Small Interfering RNA (siRNA) (1) SOD (1) Sodium Channel (8) Sodium Chloride Cotransporter (NCC) (1) Somatostatin Receptor (2) STAT (3) TGF-beta/Smad (6) TNF Receptor (3) Toll-like Receptor (TLR) (4) TRP Channel (3) VEGFR (1) β-catenin (1)
By Research Areas:	Cancer (123) Cardiovascular Disease (429) Endocrinology (42) Infection (32) Inflammation/Immunology (67) Metabolic Disease (64) Neurological Disease (58)
Click Chemistry:	Azide (5) Alkynes (4)
Oligonucleotides:	Nucleoside Analogs (52) Uridine (51) Phospholipids (1) siRNA drugs (1) Uracil (5) Phosphoramidites (5) Antisense Oligonucleotides (3) Chelating Agents (1) siRNAs (1)

548

Inhibitors & Agonists

Screening-Bibliotheken

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-B0782

Acetazolamide 10+ Cited Publications	Carbonic Anhydrase Autophagy Bacterial	Cardiovascular Disease Cancer
Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities .

HY-17404

Cilnidipine 4 Publications Verification FRC-8653	Calcium Channel	Cardiovascular Disease
Cilnidipine is a long-acting, second-generation dihydropyridine Ca ²⁺-channel blocker on L and N-type Ca ²⁺ channel . Antihypertensive effects .

HY-108286

Talinolol Cordanum	Adrenergic Receptor	Cardiovascular Disease
Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity .

HY-15834A

Eprosartan mesylate 4 Publications Verification SKF-108566J	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensin II receptor with IC₅₀s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-B0782A

Acetazolamide sodium 10+ Cited Publications	Carbonic Anhydrase Autophagy Bacterial	Infection Cardiovascular Disease Metabolic Disease Cancer
Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities .

HY-B0354A

Urapidil hydrochloride	5-HT Receptor Adrenergic Receptor	Cardiovascular Disease Infection Neurological Disease Metabolic Disease
Urapidil hydrochloride is an orally active and blood-brain barrier permeability α1-adrenoceptor antagonist and 5-HT_1A receptor agonist with a pIC₅₀ of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect .

HY-152899

Selachyl alcohol	Endogenous Metabolite	Cardiovascular Disease
Selachyl alcohol is an orally active antihypertensive agent. Selachyl alcohol has similar activities with antihypertensive neutral renomedullary lipid (ANRL). Selachyl alcohol is an alkylglycerol compound in shark liver oil mixture with properties that reduce lung metastasis. Selachyl alcohol can be used for cardiovascular disease research .

HY-107318

Alacepril Cetapril; DU-1219	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Alacepril (Cetapril) is an orally active angiotensin converting enzyme (ACE) inhibitor with long lasting antihypertensive effect .

HY-12760

Indoramin Indoramine; Wy 21901	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α_1A-adrenoceptor .

HY-P10933

PRO20	Renin	Cardiovascular Disease
PRO20 is a specific and competitive (pro)renin receptor (PRR) antagonist. PRO20 inhibits Prorenin-induced calcium influx with an IC₅₀ value of 81 nmol/L. PRO20 exerts antihypertensive activity by blocking the binding of prorenin to the PRR, inhibiting the activation of the renin-angiotensin system (RAS), and reducing the production of angiotensin II (Ang II). PRO20 is promising for research of antihypertensive agents .

HY-152358

N3-Methyl-2’-O-methyluridine	Nucleoside Antimetabolite/Analog	Others
N3-Methyl-2’-O-methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-101656

Medroxalol RMI81968	Adrenergic Receptor	Cardiovascular Disease
Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects .

HY-119667

Enrasentan SB 217242	Endothelin Receptor	Cardiovascular Disease
Enrasentan (SB 217242) is an endothelin (ET) receptor antagonist. Enrasentan has antihypertensive effects .

HY-114424A

H-Ile-Pro-Pro-OH hydrochloride 1 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide , inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM . Antihypertensive tripeptides .

HY-B1800

Tolonidine	Angiotensin Receptor	Cardiovascular Disease
Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties .

HY-N7800

Himbacine (+)-Himbacine	Others	Cardiovascular Disease
Himbacine ((+)-Himbacine) is a potent antihypertensive agent. Himbacine decreases in both mean blood pressure and heart rate .

HY-106570

Tripamide	Potassium Channel	Metabolic Disease
Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent .

HY-152732

6-Methyluridine	Nucleoside Antimetabolite/Analog	Others
6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-154285

3’-O-(2-Methoxyethyl) uridine	Nucleoside Antimetabolite/Analog	Cancer
3’-O-(2-Methoxyethyl) uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-B0354AR

Urapidil hydrochloride (Standard)	Reference Standards 5-HT Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
Urapidil (hydrochloride) (Standard) is the analytical standard of Urapidil (hydrochloride). This product is intended for research and analytical applications. Urapidil hydrochloride is an orally active α1-adrenoceptor antagonist and 5-HT_1A receptor agonist with a pIC₅₀ of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect .

HY-154466

5’-O-(4,4’-Dimethoxytrityl)-3’-O-methyluridine	Nucleoside Antimetabolite/Analog	Cancer
5’-O-(4,4’-Dimethoxytrityl)-3’-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-48973

2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite	Nucleoside Antimetabolite/Analog Phosphoramidites	Others
2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-B0757

Vitamin E nicotinate	Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology
Vitamin E nicotinate is the derivative of Vitamin E. Vitamin E nicotinate exhibits antioxidant activity and prevents lipid peroxidation. Vitamin E nicotinate upregulates levels of CD4+ T cells and IL-2, exhibits immunomodulatory activity. Vitamin E nicotinate exhibits antiplatelet and antihypertensive activities, that can be used in atherosclerosis and thrombosis ressearch .

HY-154358

4’-alpha-C-Allyl-2’,3’-bis(O-t-butyldimethylsilyl) uridine	Nucleoside Antimetabolite/Analog	Cancer
4’-alpha-C-Allyl-2’,3’-bis(O-t-butyldimethylsilyl) uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-147267

Evazarsen ISIS-757456	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Evazarsen is an angiotensinogen synthesis inhibitor and possesses antihypertensive properties .

HY-121232

Delapril CV-3317	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity .

HY-106538

Cadralazine ISF 2469	Drug Derivative	Cardiovascular Disease
Cadralazine (ISF 2469) is an orally active antihypertensive agent. Cadralazine is a peripheral arteriolar vasodilator .

HY-114424

H-Ile-Pro-Pro-OH	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Ile-Pro-Pro-OH, a milk-derived peptide , inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM . Antihypertensive tripeptides .

HY-W700616

Cicletanine hydrochloride	NO Synthase Drug Derivative	Cardiovascular Disease
Cicletanine hydrochloride is an orally active Furopyridine-derivative antihypertensive agent. Cicletanine hydrochloride stimulates NO release. Cicletanine hydrochloride induces effective pulmonary vasodilation .

HY-W020098

2'-C-methyluridine	Nucleoside Antimetabolite/Analog	Cancer
2'-C-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-N10020

Patulitrin	Lipoxygenase	Inflammation/Immunology
Patulitrin has scavenging effect in the DPPH radical. Patulitrin inhibits soybean lipoxygenase. Patulitrin also has antihypertensive effect. Patulitrin is an antioxidant flavonoid that can be isolated from Anthemis tinctoria .

HY-19291

DL-017	Adrenergic Receptor Sodium Channel	Cardiovascular Disease
DL-017 is a Quinazoline derivative. DL-017 shows inhibitory constants of approximately 0.90 nM for α1-adrenergic receptors and 404 nM for Na ⁺ channels. DL-017 exerts antihypertensive effect .

HY-W726640

Peraquinsin	MAPKAPK2 (MK2)	Cardiovascular Disease Metabolic Disease
Peraquinsin is a MK2 activator. Peraquinsin can be used for the research of vascular disorder or endothelial barrier disorder. Peraquinsin also is an antihypertensive agent .

HY-154488

3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine	Nucleoside Antimetabolite/Analog	Cancer
3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-U00301

Anti-hypertensive sulfonanilide 1	Drug Derivative	Cardiovascular Disease
Anti-hypertensive sulfonanilide 1 is a potent antihypertensive agent extracted from patent EP0338793A2, compound XVIIIa,b*, example No.1.

HY-155042

Antihypertensive agent 3	Angiotensin Receptor	Cardiovascular Disease
Antihypertensive agent 3 (compound 4a) is an antagonis of angiotensin II receptor 1. Antihypertensive agent 3 exhibits antihypertensive activity in a spontaneously hypertensive rats (SHRs) model .

HY-147406A

Tonlamarsen sodium ION-904 sodium	Endogenous Metabolite	Cardiovascular Disease
Tonlamarsen sodium is a angiotensinogen synthesis reducer, with antihypertensive activity .

HY-155041

Antihypertensive agent 2	Angiotensin Receptor	Cardiovascular Disease
Antihypertensive agent 2 (Compound 4g) is an antihypertensive agent. Antihypertensive agent 2 has effective antagonistic activities against angiotensin II receptor 1. Antihypertensive agent 2 reduces the blood pressure with equal or more potency compared to Losartan (HY-17512) .

HY-121180

A-58365B	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
A-58365B is an Angiotensin-converting Enzyme (ACE) inhibitor. A-58365B has antihypertensive effects .

HY-147267A

Evazarsen sodium ISIS-757456 sodium	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Evazarsen sodium is an angiotensinogen synthesis inhibitor and possesses antihypertensive properties .

HY-118492

Riodipine Foridon; PP-1466	Calcium Channel	Cardiovascular Disease Metabolic Disease
Riodipine (PP-1466) is a vasodilator. Riodipine can be used for the research of antihypertensive .

HY-16213

FURNIDIPINE CRE 319	Calcium Channel	Cardiovascular Disease
FURNIDIPINE, an orally active cardio-protective agent, possesses anti-arrhythmic and antihypertensive effects .

HY-164648

Flosatidil SL 85-1016	Calcium Channel	Cardiovascular Disease
Flosatidil (SL 85.1016) is an orally active Calcium Channel antagonist. Flosatidil has antianginal and antihypertensive properties .

HY-15553B

Mibefradil dihydrochloride hydrate Ro 40-5967 dihydrochloride hydrate	Calcium Channel	Cardiovascular Disease Cancer
Mibefradil dihydrochloride hydrate (Ro 40-5967 dihydrochloride hydrate) is a effectively long-acting calcium channel antagonist, used as an antihypertensive agent. Mibefradil dihydrochloride hydrate acts via a higher affinity block for low-voltage-activated (T) than for high-voltage-activated (L) calcium channels .

HY-19367

MD-39-AM	Drug Intermediate	Cardiovascular Disease
MD-39-AM exhibits antihypertensive, diuretic and saliuretic activities with good in vivo pharmacokinetic characters .

HY-120134

BMS 183920	Angiotensin Receptor	Cardiovascular Disease
BMS 183920 is a diacidic and potent angiotensin II receptor antagonist, with a K_i value of 2.9 nM in the rat adrenal cortex binding assay and a K_B value of 0.061 nM in the rabbit aorta functional assay. BMS 183920 can be used for research of antihypertensive .

HY-101656A

Medroxalol hydrochloride RMI81968 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Medroxalol hydrochloride is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol hydrochloride shows antihypertensive and vasodilating effects .

HY-107326

Bunazosin	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Bunazosin is a potent and selective α1-adrenoceptor antagonist. Bunazosin can be used for antihypertensive and ocular hypotensive research .

HY-107326A

Bunazosin hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Bunazosin hydrochloride is a potent and selective α1-adrenoceptor antagonist. Bunazosin hydrochloride can be used for antihypertensive and ocular hypotensive research .

HY-12760R

Indoramin (Standard) Indoramine (Standard); Wy 21901 (Standard)	Adrenergic Receptor Reference Standards	Cardiovascular Disease Endocrinology
Indoramin (Standard) is the analytical standard of Indoramin. This product is intended for research and analytical applications. Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor .

Art. -Nr.	Produktname

HY-L145

Antihypertensive Compound Library

893 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 893 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

HY-L117

Calcium Channel Blocker Library

217 compounds

Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

MCE supplies a unique collection of 217 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

Art. -Nr.	Produktname	Type

HY-15371G

Forskolin

Coleonol; Colforsin; HL 362

Fluorescent Dyes

Forskolin (Coleonol) (GMP) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin (GMP) is also an inducer of intracellular cAMP formation . Forskolin (GMP) induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR . Forskolin (GMP) exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin (GMP) also induces autophagy .

HY-D2428

OVA-PEG-Cy3

Fluorescent Dyes

OVA-PEG-Cy3 is a Cy3 (HY-D0822)-labeled OVA-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Ovalbumins (OVA), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues .

Art. -Nr.	Produktname	Type

HY-W250978

Ovalbumins

4 Publications Verification

Biochemical Assay Reagents

Ovalbumins (OVA), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues .
We recommend using Ovalbumin, low endotoxin (HY-W250978A) to establish an asthma model.

HY-W250978A

Ovalbumin, low endotoxin

Biochemical Assay Reagents

Ovalbumin, low endotoxin (OVA, low endotoxin), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues . Ovalbumin, a low endotoxin, can be used to establish an asthma model .

HY-D0850

Tartaric acid disodium dihydrate

Sodium tartrate dibasic dihydrate; Sodium tartrate dihydrate

Biochemical Assay Reagents

Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications .

HY-15371G

Forskolin

Coleonol; Colforsin; HL 362

Biochemical Assay Reagents

HY-W109973

L-Tartaric acid diammonium

L-(+)-Tartaric acid diammonium

Biochemical Assay Reagents

L-Tartaric acid diammonium (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. L-Tartaric acid diammonium has vasodilatory and antihypertensive effects. L-Tartaric acid diammonium can be used as flavorings and antioxidants in a range of foods and beverages. L-Tartaric acid diammonium can be used in laser frequency doubling and optical limiting applications .

HY-D0850R

Tartaric acid disodium dihydrate (Standard)

Sodium tartrate dibasic dihydrate (Standard); Sodium tartrate dihydrate (Standard)

Biochemical Assay Reagents

Tartaric acid (disodium dihydrate) (Standard) is the analytical standard of Tartaric acid (disodium dihydrate). This product is intended for research and analytical applications. Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications [4].

Art. -Nr.	Produktname	Target	Research Area

HY-P1944

Apelin-13 Maximum Cited Publications 10 Publications Verification	Apelin Receptor (APJ)	Cardiovascular Disease Metabolic Disease
Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC₅₀ value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome .

HY-P1944A

Apelin-13 TFA Maximum Cited Publications 10 Publications Verification	Apelin Receptor (APJ)	Cardiovascular Disease Metabolic Disease
Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC₅₀ value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome .

HY-P3108

Alamandine 2 Publications Verification	Angiotensin Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions .

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide 1 Publications Verification	Adenylate Cyclase PTHR	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is an endogenous PTH2 receptor agonist and antihypertensive agent. TIP 39, Tuberoinfundibular Neuropeptide selectively activates the PTH2 receptor with no activity on the PTH1 receptor, stimulates cAMP production, activates adenylate cyclase, and elevates intracellular calcium levels via mobilization from intracellular stores. TIP 39, Tuberoinfundibular Neuropeptide is highly conserved in humans, mice, and rats. TIP 39, Tuberoinfundibular Neuropeptide is applicable to research related to nociception and inflammation-induced pain .

HY-106103

Seglitide MK-678; L-363586	Somatostatin Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Seglitide (MK-678) is a potent, orally active somatostatin receptor 2 (SSTR₂) agonist, and also a competitive antagonist of SSTR₁₄, SSTR₂₅, and SSTR₂₈. Seglitide has antihypertensive effects and can inhibit plasma glucagon and growth hormone. Seglitide can be used for research on diabetes .

HY-P10933

PRO20	Renin	Cardiovascular Disease
PRO20 is a specific and competitive (pro)renin receptor (PRR) antagonist. PRO20 inhibits Prorenin-induced calcium influx with an IC₅₀ value of 81 nmol/L. PRO20 exerts antihypertensive activity by blocking the binding of prorenin to the PRR, inhibiting the activation of the renin-angiotensin system (RAS), and reducing the production of angiotensin II (Ang II). PRO20 is promising for research of antihypertensive agents .

HY-128696

Amlodipine aspartic acid impurity Amlodipine aspartate	Drug Metabolite Calcium Channel	Cardiovascular Disease
Amlodipine aspartic acid impurity (Amlodipine aspartate) is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension .

HY-P4641

H-Trp-Phe-OH Trp-Phe	Angiotensin-converting Enzyme (ACE) Endothelin Receptor	Cardiovascular Disease
H-Trp-Phe-OH (Trp-Phe) is an ACE inhibitor and endothelial function regulator, with an ACE IC₅₀ of 0.318 mg/mL. H-Trp-Phe-OH increases nitric oxide concentration, reduces endothelin-1 (ET-1) levels, and reverses norepinephrine-mediated endothelial cell dysfunction. H-Trp-Phe-OH exhibits antihypertensive activity. H-Trp-Phe-OH can be used in studies related to hypertension and atherosclerosis .

HY-114424A

H-Ile-Pro-Pro-OH hydrochloride 1 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide , inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM . Antihypertensive tripeptides .

HY-P11300

YKYY	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
YKYY, a antihypertensive peptide, is an Angiotensin I-converting enzyme (ACE) inhibitor with an IC₅₀ of 64.2 μM. YKYY can be isolated for the peptic digest of wakame Undaria pinnatifida. YKYY can be used for hypertension research .

HY-P3395

Catestatin (human) Human chromogranin A 352–372	nAChR	Cardiovascular Disease Inflammation/Immunology
Catestatin human, a catecholamine release-inhibitory peptide, is a pleiotropic peptide involved in cardiovascular protection with its antihypertensive and angiogenic effects. Catestatin human can be used in the study of inflammatory diseases .

HY-106103A

Seglitide acetate MK 678 acetate; L 36358 acetate	Somatostatin Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Seglitide acetate (MK 678; L 36358 acetate) is a potent, orally active somatostatin receptor 2 (SSTR₂) agonist, and also a competitive antagonist of SSTR₁₄, SSTR₂₅, and SSTR₂₈. Seglitide acetate has antihypertensive effects and can inhibit plasma glucagon and growth hormone. Seglitide acetate can be used for research on diabetes .

HY-P11300A

YKYY TFA	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
YKYY TFA is a blood pressure-lowering peptide isolated from the digest of Undaria pinnatifida. It is an angiotensin I-converting enzyme (ACE) inhibitor with an IC₅₀ of 64.2 μM. YKYY FTA can be used in hypertension research .

HY-P10601A

αs1-CN f(143–149) acetate	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
αs1-CN f(143–149) acetate is an orally active casein-derived peptide sequence. αs1-CN f(143–149) acetate exhibits angiotensin-converting enzyme (ACE) inhibitory activity (IC₅₀=6.58 μM) and antihypertensive activity .

HY-P4650

Tyrosylhistidine	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Tyrosylhistidine is a dipeptide consisting of tyrosine and histidine (Tyr-His). Tyrosylhistidine is an orally active antihypertensive peptide. Tyrosylhistidine reduces blood pressure in mice in a model of spontaneous hypertension .

HY-114424

H-Ile-Pro-Pro-OH	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Ile-Pro-Pro-OH, a milk-derived peptide , inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM . Antihypertensive tripeptides .

HY-P10601

αs1-CN f(143–149)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
αs1-CN f(143–149) is an orally active casein-derived peptide sequence. αs1-CN f(143–149) exhibits angiotensin-converting enzyme (ACE) inhibitory activity (IC₅₀=6.58 μM) and antihypertensive activity .

HY-P3050

Helospectin II	GCGR	Cardiovascular Disease
Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum .

HY-P10092

SP6	Akt NO Synthase PI3K	Cardiovascular Disease
SP6 exertes an antihypertensive effect through vascular NO regulation .

HY-P2072

GF109	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
GF109 is a potent parenteral inhibitor of angiotensin converting enzyme (ACE). GF109 has antihypertensive effects .

HY-P3053

Helospectin I	GCGR	Cardiovascular Disease
Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum .

HY-P10808

RSRGVFF	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
RSRGVFF (FOXP3 inhibitor P60) is a mixed-type angiotensin-converting enzyme (ACE) inhibitor with blood-brain barrier permeability, boasting an IC₅₀ value of 5.01 μM . RSRGVFF is capable of binding to both active and non-active sites of ACE and its substrate HHL complex, thus reducing the catalytic activity of ACE. RSRGVFF can be further utilized for research on lowering hypertension .

HY-P0318

Hemorphin-7	Opioid Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).

HY-W012159

Methionylserine H-MET-SER-OH	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a K_m value of 0.2 mM. Methionylserine inhibits ACE enzyme activity. Methionylserine can be used in the research of hypension .

HY-128696R

Amlodipine aspartic acid impurity (Standard) Amlodipine aspartate (Standard)	Drug Metabolite Reference Standards Calcium Channel	Cardiovascular Disease
Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension .

HY-P10616

Salusin-α	Endogenous Metabolite	Cardiovascular Disease
Salusin-α is an endogenous bioactive peptide with hemodynamic and cell proliferation activities. Salusin-α can stimulate the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, leading to a rapid and significant decrease in blood pressure and heart rate, but its effect is weaker than that of Salusin-β (HY-P10617). Salusin-α has potential application value in cardiovascular disease research .

HY-P11411

[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat	Neuropeptide Y Receptor Histamine Receptor	Cardiovascular Disease
[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat is a fragment analogue of a neuropeptide Y (NPY) with cardiovascular activity. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can induce profound and sustained hypotension in both hypertensive and normotensive rats and its antihypertensive effect is partly attributed to its activity on histamine receptor. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can be used for studying antihypertensive effects .

HY-P3872

Peptide B, bovine	Peptides	Inflammation/Immunology
Peptide B, bovine is an immunoregulatory peptide in bovine milk. Peptide B, bovine comes from αs1-casein B-8P (f1-13), is the major peptide produced during the ripening process with antihypertensive effects .

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-15371

Forskolin Maximum Cited Publications 210 Publications Verification Coleonol; Colforsin; HL 362	Classification of Application Fields Terpenoids Labiatae Metabolic Disease Diterpenoids Plants Inflammation/Immunology Disease Research Fields Endocrinology Pueraria montana (Lour.) Merr. Source Classification	Organoid Adenylate Cyclase FXR Autophagy PKC
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR . Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-B0112

Minoxidil 10+ Cited Publications U10858	Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Potassium Channel Endogenous Metabolite
Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 μM .

HY-N0669

Stevioside 4 Publications Verification	Trifolium hybridum L. Classification of Application Fields Terpenoids Diterpenoids Plants Compositae Disease Research Fields Sweeteners Source Classification Cancer Food Research	Apoptosis
Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities .

HY-N1919

Ajmalicine 2 Publications Verification Raubasine	Iridoids Classification of Application Fields Terpenoids Rosaceae Plants Disease Research Fields Endocrinology Source Classification Rosa multifoloraThunb	Adrenergic Receptor Cholinesterase (ChE)
Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α₁-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC₅₀ of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity .

HY-N0217

Benzoylaconine 1 Publications Verification Benzoylaconitine; Isaconitine; Pikraconitin	Alkaloids Classification of Application Fields Other Alkaloids Ranunculaceae Other Diseases Aconitum carmichaeli Debx. Plants Disease Research Fields Source Classification	Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) NF-κB COX NO Synthase p38 MAPK P-glycoprotein
Benzoylaconine (Benzoylaconitine) is an orally active monoester alkaloid found in the traditional Chinese medicine Aconitum carmichaelii. Benzoylaconine is an ACE2 agonist (EC₅₀: 1.5 μM) with antihypertensive and anti-heart failure effects. Benzoylaconine inhibits TLR-induced MAPK and NF-κB pathways to exert anti-inflammatory effects. Benzoylaconine upregulates the protein levels of P-gp, MRP2, and has anti-tumor effects .

HY-N0719

Fargesin 2 Publications Verification	Cardiovascular Disease Classification of Application Fields Magnoliaceae Lignans Magnolia Liliflora Desr. Phenylpropanoids Plants Disease Research Fields Source Classification	AP-1
Fargesin is a bioactive neolignan isolated from magnolia plants, with antihypertensive and anti-inflammatory effects .

HY-15449

Kaempferide 5+ Cited Publications Kaempferol 4'-O-methyl ether	Infection Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Source Classification Zingiberaceae	Estrogen Receptor/ERR Autophagy Bacterial Influenza Virus Apoptosis PI3K Akt GSK-3 FOXO β-catenin
Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research .

HY-N1458

Isoschaftoside 1 Publications Verification	Classification of Application Fields Flavones Plants Desmodium uncinatum DC. Infection Flavonoids other families Leguminosae Phenols Polyphenols Disease Research Fields Source Classification Cancer	Parasite Autophagy p62 Reactive Oxygen Species (ROS)
Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit the growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study .

HY-N0563

Alizarin 1 Publications Verification	Quinones Classification of Application Fields Anthraquinones Rubiaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Rubia cordifolia L. Source Classification	AMPK VEGFR PI3K Akt NF-κB Cytochrome P450
Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings .

HY-128741

D-Allose	Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite Reactive Oxygen Species (ROS) Apoptosis Toll-like Receptor (TLR) PI3K Akt
D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities .

HY-107339

Deserpidine Harmonyl	Apocynaceae Alkaloids Piperidine Alkaloids Plants Rauwolfia canescens Indole Alkaloids	Angiotensin-converting Enzyme (ACE)
Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex .

HY-125130

Hesperetin 7-O-glucoside 1 Publications Verification Hes-7-G	Flavonoids Classification of Application Fields Flavonones Phenols Polyphenols Metabolic Disease Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	HMG-CoA Reductase (HMGCR) Bacterial Interleukin Related
Hesperetin 7-O-glucoside is a typical flavonoid monoglucoside, which is an anti-inflammatory agent and an antihypertensive with orally active. Hesperetin 7-O-glucoside is a commonly used food adjuvant. Hesperetin 7-O-glucoside inhibits human intestinal maltase and human HMG-CoA reductase with K_i of 1.8 mM and 9.8 μM, respectively. Hesperetin 7-O-glucoside has antibacterial activity and can regulate intestinal flora and metabolic homeostasis in mice .

HY-N2488

Demethylsuberosin 4 Publications Verification 7-Demethylsuberosin	Monophenols Classification of Application Fields Coumarins Phenols Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Echinacea angustifolia DC. Source Classification	Calcium Channel NO Synthase
Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type Ca_V1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells .

HY-118472

Benazeprilat CGS 14831	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite Angiotensin-converting Enzyme (ACE)
Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .

HY-N2555

Tilianin 2 Publications Verification	Cardiovascular Disease Monophenols Flavonoids Classification of Application Fields Flavones Labiatae Phenols Plants Inflammation/Immunology Disease Research Fields Crotalaria candicans Wight & Arn. Source Classification	Others
Tilianin is an active flavonoid glycoside found in many medical plants, with potential anti-hypertensive, myocardial-protective, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and antioxidant effects .

HY-N0766

Isorhynchophylline 2 Publications Verification	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Classification of Application Fields Rubiaceae Other Diseases Plants Disease Research Fields Indole Alkaloids Source Classification	SOD NF-κB
Isorhynchophylline is an alkaloid isolated from Crocus sativus with anticancer, antihypertensive, anti-inflammatory, and neuroprotective properties. Isorhynchophylline can be applied to cardiovascular and neurological disorders, and cancer studies .

HY-W005255

3-(3-Hydroxyphenyl)propionic acid	Cardiovascular Disease Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-(3-Hydroxyphenyl)propionic acid (3HPPA) is an endothelium-dependent nitric oxide (NO) release promoter and endothelial nitric oxide synthase (eNOS) activator. 3-(3-Hydroxyphenyl)propionic acid activates eNOS to mediate vascular smooth muscle relaxation and enhances endothelial cell NO synthesis, inducing vasodilation and reducing peripheral vascular resistance. 3-(3-Hydroxyphenyl)propionic acid can dose-dependently reduce systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR) without affecting cardiac contractility or heart rate. 3-(3-Hydroxyphenyl)propionic acid has antihypertensive and vascular protective effects and can be used in the prevention and treatment of cardiovascular diseases .

HY-N0214

Peimisine 3 Publications Verification Ebeiensine	Alkaloids Piperidine Alkaloids Liliaceae Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Fritillaria cirrhosa Source Classification	mAChR Angiotensin-converting Enzyme (ACE) Apoptosis
Peimisine (Ebeiensine) is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research .

HY-B0935

Benzyl benzoate 1 Publications Verification Phenylmethyl benzoate	Infection Structural Classification Natürliche Produkte Classification of Application Fields Uvaria grandiflora Roxb. Essence, Fragrance Cosmetic Research Plants Annonaceae Disease Research Fields Source Classification	Environmental Pollutants Angiotensin Receptor Endogenous Metabolite Fungal Bacterial Parasite
Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC₅₀= 0.06 g/m ²) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry .

HY-N1377

Nevadensin Lysionotin	Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Metabolic Disease Plants Inflammation/Immunology Disease Research Fields Source Classification	Carboxylesterase (CES) DNA/RNA Synthesis Apoptosis Bacterial
Nevadensin (Lysionotin), a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC₅₀ of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC₅₀ of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities .

HY-W015590

2-Hydroxyphenylacetic acid	Structural Classification Monophenols Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Drug Metabolite Fungal
2-Hydroxyphenylacetic acid is a metabolite of Phenylalanine and Tyrosine, as well as a product of the biotransformation of Phenylacetonitrile by marine fungi. 2-Hydroxyphenylacetic acid acts as a potential biomarker for food. 2-Hydroxyphenylacetic acid slightly induces the expression of green fluorescent protein. 2-Hydroxyphenylacetic acid is used in the research of phenylketonuria and related hyperphenylalaninemia .

HY-152899

Selachyl alcohol	Cardiovascular Disease Natürliche Produkte Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Selachyl alcohol is an orally active antihypertensive agent. Selachyl alcohol has similar activities with antihypertensive neutral renomedullary lipid (ANRL). Selachyl alcohol is an alkylglycerol compound in shark liver oil mixture with properties that reduce lung metastasis. Selachyl alcohol can be used for cardiovascular disease research .

HY-15371R

Forskolin (Standard) Coleonol (Standard); Colforsin (Standard); HL 362 (Standard)	Structural Classification Terpenoids Labiatae Diterpenoids Plants Pueraria montana (Lour.) Merr. Source Classification	Organoid Reference Standards Adenylate Cyclase FXR Autophagy PKC
Forskolin (Standard) is the analytical standard of Forskolin. This product is intended for research and analytical applications. Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR . Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-N7676

Marein 3 Publications Verification	Cardiovascular Disease Chalcones Flavonoids other families Neurological Disease Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	AMPK HDAC
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

HY-W018197

2-Phenylacetamide	Natürliche Produkte Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite p38 MAPK Reactive Oxygen Species (ROS)
2-Phenylacetamide is a estrogen-like compound that can be isolated from Lepidium apetalum seeds. 2-Phenylacetamide inhibits p38 MAPK signaling pathway, exhibits anti-inflammatory, antioxidant, anti-hypertensive, and anti-fibrosis effects. 2-Phenylacetamide is orally active .

HY-N0081

(±)-Praeruptorin A	Infection Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Plants Disease Research Fields Source Classification	Calcium Channel NF-κB Interleukin Related
(±)-Praeruptorin A, a coumarin compound, is the main bioactive component in Peucedani Radix. As a calcium channel blocker, (±)-Praeruptorin A exhibits great antihypertensive effects. In addition, (±)-Praeruptorin A also has the effects of relaxing vascular smooth muscle, inhibiting airway inflammation and airway hyperresponsiveness. (±)-Praeruptorin A can be used for the research of allergic asthma, hypertension and other diseases .

HY-B0112R

Minoxidil (Standard) U10858 (Standard)	Structural Classification Alkaloids Piperidine Alkaloids Endogenous metabolite Source Classification	Reference Standards Potassium Channel Endogenous Metabolite
Minoxidil (Standard) is the analytical standard of Minoxidil. This product is intended for research and analytical applications. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM .

HY-N6969

Dicentrine	Alkaloids Structural Classification Classification of Application Fields Stephania epigaea Lo Plants Isoquinoline Alkaloids Menispermaceae Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor
Dicentrine is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an α₁-adrenoceptor antagonist which has effective against human hyperplastic prostates .

HY-N9351

Cleistanthin B Diphyllin O-glucoside	Cardiovascular Disease Infection other families Classification of Application Fields Lignans Metabolic Disease Phenylpropanoids Plants Disease Research Fields Source Classification	SARS-CoV
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC₅₀ of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo .

HY-141581

Lyso-PAF C-18	Cardiovascular Disease Natürliche Produkte Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Platelet-activating Factor Receptor (PAFR) Endogenous Metabolite
Lyso-PAF C-18 is an intermediate for the synthesis of C18-PAF (HY-130345). It has an easily substituted "Lyso-PAF" structure and is easy to purify and has high yield. C18-PAF is a ligand for platelet-activating factor and PAF G protein-coupled receptor (PAFR) and has renovasodilator properties and antihypertensive lipid properties .

HY-W001940

DL-m-Tyrosine	Cardiovascular Disease Structural Classification Monophenols Animals Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Source Classification	Amino Acid Derivatives Bacterial
DL-m-Tyrosine is a non-protein amino acid. DL-m-Tyrosine inhibits microbial growth and spore formation. DL-m-Tyrosine also inhibits root growth in various plants, such as lettuce and Arabidopsis. DL-m-Tyrosine, when used in combination with Carbidopa (HY-B0311), has a potent antihypertensive effect. DL-m-Tyrosine can be used in research on biopesticide design .

HY-N0669R

Stevioside (Standard)	Structural Classification Trifolium hybridum L. Terpenoids Diterpenoids Plants Compositae Source Classification	Reference Standards Apoptosis
Stevioside (Standard) is the analytical standard of Stevioside. This product is intended for research and analytical applications. Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities .

HY-N9347

Stepharine 3 Publications Verification	Cardiovascular Disease Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Toll-like Receptor (TLR)
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects .

HY-N7800

Himbacine (+)-Himbacine	Alkaloids other families Galbulimima baccata Quinoline Alkaloids Plants Source Classification	Others
Himbacine ((+)-Himbacine) is a potent antihypertensive agent. Himbacine decreases in both mean blood pressure and heart rate .

HY-N3931

Gardneramine	Alkaloids Nepenthes mirabilis (Lour.) Druce Plants Nepenthaceae Source Classification	Others
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines .

HY-N10020

Patulitrin	Flavonols Flavonoids Ohwia caudata (Thunberg) H. Ohashi Plants Compositae Source Classification	Lipoxygenase
Patulitrin has scavenging effect in the DPPH radical. Patulitrin inhibits soybean lipoxygenase. Patulitrin also has antihypertensive effect. Patulitrin is an antioxidant flavonoid that can be isolated from Anthemis tinctoria .

HY-N0214A

Peimisine hydrochloride 3 Publications Verification Ebeiensine hydrochloride	Alkaloids Piperidine Alkaloids Liliaceae Classification of Application Fields Fritillaria ussuriensis Maxim. Plants Inflammation/Immunology Disease Research Fields Source Classification	mAChR Angiotensin-converting Enzyme (ACE) Apoptosis
Peimisine (Ebeiensine) hydrochloride is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine hydrochloride shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research .

HY-N16467

Uncarine F Speciofiline	Structural Classification Alkaloids Oxindole Alkaloids Rubiaceae Plants Mitragyna parvifolia (Roxb.) Korth. Source Classification	Others
Uncarine F (Speciofiline) is a pentacyclic oxindole alkaloid found in Uncaria tomentosa. Uncaria alkaloids have wide medicinal properties, including neuroprotective, anticancer, and antihypertensive activities. Uncaria alkaloids may stimulate the immune system, relax smooth muscles, dilate blood vessels, and act as a diuretic. Uncarine F can be used for the researches of cancer, immunology, cardiovascular and neurological disease .

HY-N14880

Oudenone	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Oudenone is an oxygen-containing heterocyclic antibiotic. Oudenone has weak antibacterial and fungal activity. Oudenone has antihypertensive effect on spontaneous hypertension in rats by intraperitoneal injection or oral administration .

HY-N1919R

Ajmalicine (Standard) Raubasine (Standard)	Structural Classification Iridoids Terpenoids Rosaceae Plants Source Classification Rosa multifoloraThunb	Reference Standards Adrenergic Receptor Cholinesterase (ChE)
Ajmalicine (Standard) is the analytical standard of Ajmalicine. This product is intended for research and analytical applications. Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity .

HY-B0935R

Benzyl benzoate (Standard) Phenylmethyl benzoate (Standard)	Structural Classification Natürliche Produkte Uvaria grandiflora Roxb. Plants Annonaceae Source Classification	Reference Standards Parasite Endogenous Metabolite Angiotensin Receptor Bacterial Fungal
Benzyl benzoate (Standard) is the analytical standard of Benzyl benzoate. This product is intended for research and analytical applications. Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC₅₀= 0.06 g/m ²) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry .

HY-147406A

Tonlamarsen sodium ION-904 sodium	Cardiovascular Disease Structural Classification Natürliche Produkte Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Tonlamarsen sodium is a angiotensinogen synthesis reducer, with antihypertensive activity .

HY-N2940

Bisandrographolide A BAA	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	TRP Channel
Bisandrographolide A (BAA) activates TRPV4 channel with an EC₅₀ of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound .

HY-107339R

Deserpidine (Standard) Harmonyl (Standard)	Apocynaceae Alkaloids Piperidine Alkaloids Structural Classification Plants Rauwolfia canescens Indole Alkaloids	Reference Standards Angiotensin-converting Enzyme (ACE)
Deserpidine (Standard) is the analytical standard of Deserpidine. This product is intended for research and analytical applications. Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex .

HY-137934

Deacetylforskolin 7-Deacetylforskolin	Terpenoids Labiatae Diterpenoids Plants Pueraria montana (Lour.) Merr. Source Classification	Endogenous Metabolite
Deacetylforskolin is a deacetylated derivative of forskolin (HY-15371) that can be extracted from C. forskohlii. Deacetylforskolin activates rat adipocyte adenylyl cyclase (IC₅₀ = 20 µM), inhibits glucose transport in rat adipocyte plasma membranes and exhibits antihypertensive activity .

HY-N1458R

Isoschaftoside (Standard)	Structural Classification Flavonoids other families Flavones Leguminosae Phenols Polyphenols Plants Desmodium uncinatum DC. Source Classification	Reference Standards Parasite Autophagy p62 Reactive Oxygen Species (ROS)
Isoschaftoside (Standard) is the analytical standard of Isoschaftoside. This product is intended for research and analytical applications. Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study.

HY-N7675A

(2R)-Flavanomarein	Flavonoids Cercis chinensis Bunge Flavonones Plants Compositae Source Classification	Others
(2R)-Flavanomarein is a predominant flavonoid of Coreopsis tinctoria Nutt with protective effects against diabetic nephropathy. (2R)-Flavanomarein has good antioxidative, antidiabetic, antihypertensive and anti-hyperlipidemic activities .

HY-N0214R

Peimisine (Standard) Ebeiensine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Plants Fritillaria cirrhosa Source Classification	Reference Standards mAChR Angiotensin-converting Enzyme (ACE) Apoptosis
Peimisine (Standard) is the analytical standard of Peimisine. This product is intended for research and analytical applications. Peimisine (Ebeiensine) is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research .

HY-118472R

Benazeprilat (Standard) CGS 14831 (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Drug Metabolite Reference Standards Endogenous Metabolite Angiotensin-converting Enzyme (ACE)
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .

HY-N3103R

p-Coumaric Acid Ethyl Ester (Standard) Ethyl (E)-p-hydroxycinnamate (Standard); Ethyl trans-4-hydroxycinnamate (Standard)	Structural Classification Monophenols other families Simple Phenylpropanols Phenols Phenylpropanoids Plants Source Classification	Reference Standards Drug Metabolite
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .

Art. -Nr.	Produktname	Chemical Structure

HY-15895S

Aprocitentan-d4
Aprocitentan-d₄ is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent .

HY-23196S

Minoxidil-d10
Minoxidil-d₁₀ (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

HY-B0252S1

Hydrochlorothiazid-13C,d2

Hydrochlorothiazid- ¹³C,d₂ is the ¹³C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-B0782S

Acetazolamide-d3
Acetazolamide-d₃ is deuterium labeled Acetazolamide (HY-B0782). Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities.

HY-B0006S1

Carvedilol-d4
Carvedilol-d₄ is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker . Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .

HY-B0612DS1

Lercanidipine-d3 hydrochloride
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect .

HY-B0252S

Hydrochlorothiazid-d2

Hydrochlorothiazid-d₂ is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-B0424S

Nitrendipine-d5

Nitrendipine-d₅ is the deuterium labeled Nitrendipine (HY-B0424). Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma .

HY-B0252S3

Hydrochlorothiazide-15N2,13C,d2

Hydrochlorothiazide- ¹⁵N₂, ¹³C,d₂ is ¹⁵N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-B0409S

Clonidine-d4
Clonidine-d₄ is the deuterium labeled Clonidine. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent .

HY-B0612AS

Lercanidipine-13C,d3 hydrochloride
Lercanidipine- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Lercanidipine hydrochloride . Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect .

HY-B0309S2

Felodipine-d3
Felodipine-d₃ is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-107322S

Barnidipine-d5 hydrochloride

Barnidipine-d₅ (hydrochloride) is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors .Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action .

HY-107322AS1

Barnidipine-d5

Barnidipine-d₅ is the deuterium-labeled Barnidipine (HY-107322A). Barnidipine-d₅ (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [ ³H] initrendipine binding sites (K_i=0.21 nmol/l), has selective action against CaA receptors . Barnidipine-d₅ (Mepirodipine) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action .

HY-B0347S1

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine . Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-B0632S

Diltiazem-d6
Diltiazem-d₆ is the deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca2+ channel blocker, with antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

HY-17404S

Cilnidipine-d7
Cilnidipine-d₇ is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel . Antihypertensive effects .

HY-B0205S

Candesartan-d4
Candesartan-d₄ (CV-11974-d₄) is the deuterium labeled Candesartan (HY-B0205). Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).

HY-128741S

D-Allose-13C

D-Allose- ¹³C is the ¹³C labeled D-Allose (HY-128741). D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities .

HY-W707863

Lercanidipine-d3

Lercanidipine-d₃ is the deuterium labeled Lercanidipine (HY-B0612). Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective and orally active dihydropyridine-calcium channel blocker with a pIC₅₀ of 7.74 (converts from μM). Lercanidipine has long lasting antihypertensive action as well as reno- and neuro-protective effect. Lercanidipine also shows anti-oxidant, anti-inflammatory and anti-apoptotic properties. Lercanidipine can be used in cardiovascular and neurological research .

HY-B0561S4

Spironolactone-d6-1

Spironolactone-d₆-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

HY-B0612ES

(S)-Lercanidipine-d3 hydrochloride
(S)-Lercanidipine-d₃ hydrochloride is a deuterium labeled Lercanidipine D3 hydrochloride. (S)-Lercanidipine hydrochloride is an antihypertensive agent .

HY-117743S1

Eprosartan-d6
Eprosartan-d₆ is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC₅₀s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-117281S1

Moexipril-d3
Moexipril-d₃ is deuterated labeled Moexipril (HY-117281). Moexipril is an orally active inhibitor of angiotensin-converting enzyme (ACE), and becomes effective by being hydrolyzed to moexiprila hydrochloride. Moexipril exhibits antihypertensive and neuroprotective effects ^- .

HY-B0224S

Chlorothiazide-13C,15N2
Chlorothiazide- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Chlorothiazide . Chlorothiazide is an orally active diuretic and anti-hypertensive agent .

HY-N2392S

Kukoamine A-d8 dihydrochloride
Kukoamine A-d₈ (dihydrochloride) is deuterium labeled Kukoamine A. Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity .

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect .

HY-B0632S2

Diltiazem-d4
Diltiazem-d₄ is deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca ²⁺ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

HY-B1191S

Nanofin-d2
Nanofin-d₂ (2,6-Lupetidine-d₂) is the deuterium labeled Nanofin (HY-B1191). Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.

HY-17404S1

Cilnidipine-d4
Cilnidipine-d₄ (FRC-8653-d₄) is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca ²⁺-channel blocker on L and N-type Ca ²⁺ channel . Antihypertensive effects .

HY-17416S

Guanfacine-d2 hydrochloride
Guanfacine-d₂ (hydrochloride) is the deuterium labeled Guanfacine hydrochloride. Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors .

HY-108286S

(Rac)-Talinolol-d5
(Rac)-Talinolol-d₅ is the racemate of Talinolol. Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity .

HY-W767936

Moxonidine-13C,d3
Moxonidine- ¹³C,d₃ (BDF5895- ¹³C,d₃) is the ¹³C-labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-B0309S1

Felodipine-d5
Felodipine-d₅ is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-117743S

Eprosartan-d3
Eprosartan-d₃ is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC₅₀s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-B0252S2

Hydrochlorothiazide-13C6

Hydrochlorothiazide- ¹³C₆ is the ¹³C labeled Hydrochlorothiazide . Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-B0006S

Carvedilol-d3
Carvedilol-d₃ is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker . Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .

HY-132670S

(R)-(-)-Felodipine-d5

(R)-(-)-Felodipine-d₅ is the deuterium labeled (R)-(-)-Felodipine. (R)-(-)-Felodipine is the S enantiomer of Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-B0006S2

Carvedilol-d5
Carvedilol-d₅ is deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker . Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .

HY-15407S3

Sacubitril-13C4
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC₅₀=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .

HY-B0368S

Captopril-d3

Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-W653969

Arotinolol-d5 hydrochloride

Arotinolol-d₅ (hydrochloride) is deuterium labeled Arotinolol. Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker . Arotinolol also shows potency for inhibiting the binding of the radioligand ¹²⁵I-ICYP to 5HT_1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases .

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .

HY-W001940S

DL-m-Tyrosine-d3

DL-m-Tyrosine-d₃ is the deuterium labeled DL-m-Tyrosine (HY-W001940). DL-m-Tyrosine is a non-protein amino acid. DL-m-Tyrosine inhibits microbial growth and spore formation. DL-m-Tyrosine also inhibits root growth in various plants, such as lettuce and Arabidopsis. DL-m-Tyrosine, when used in combination with Carbidopa (HY-B0311), has a potent antihypertensive effect. DL-m-Tyrosine can be used in research on biopesticide design.

HY-B0347S3

Lacidipine-13C4

Lacidipine- ¹³C₄ is ¹³C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-W728545

Labetalol-d6 hydrochloride

Labetalol hydrochloride-d₆ (AH-5158 hydrochloride-d₆) is deuterium labeled Labetalol hydrochloride (HY-B1108). Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .

HY-128741S2

D-Allose-13C-2

D-Allose- ¹³C-2 is the ¹³C labeled D-Allose (HY-128741). D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities .

HY-128741S1

D-Allose-13C-1

D-Allose- ¹³C-1 is the ¹³C labeled D-Allose (HY-128741). D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities .

HY-B0368S1

Captopril-13C5,15N

Captopril- ¹³C₅, ¹⁵N (SQ 14225- ¹³C₅, ¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-W042301S

Xipamide-d6
Xipamide-d₆ is the deuterium labeled Xipamide. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

Art. -Nr.	Produktname		Classification

HY-A0091A

Pargyline 3 Publications Verification		Alkynes
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline has antihypertensive and anticancer activities . Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0091

Pargyline hydrochloride 3 Publications Verification		Alkynes
Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline hydrochloride has antihypertensive and anticancer activities . Pargyline (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-152782

4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine		Azide
4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152476

3’-β-C-Ethynyluridine		Alkynes
3’-β-C-Ethynyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-β-C-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154736

N3-(Butyn-3-yl)uridine		Alkynes
N3-(Butyn-3-yl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . N3-(Butyn-3-yl)uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-152985

3’-Azido-3’-deoxy-4-deoxyuridine		Azide
6-Chloro-N1-(trimethylsilylethoxymethyl)pseudouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-Azido-3’-deoxy-4-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154590

2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine		Azide
2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154357

4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine		Azide
4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-129737

A-62198		Azide
A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses .

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-107632G

GYY4137	Apoptosis STAT NF-κB TNF Receptor NO Synthase Interleukin Related COX	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
GYY4137 (GMP) is the GMP-grade version of GYY4137 (HY-107632). Small molecules of GMP grade can be used as adjuvant reagents in cell therapy. GYY4137 (GMP) is a sustained-release H2S donor possessing vasodilatory, antihypertensive, and anti-inflammatory activities. GYY4137 (GMP) can inhibit cell growth, induce apoptosis, and cause cell cycle arrest by blocking the STAT3 pathway, demonstrating potent anticancer activity .

HY-15371G

Forskolin Coleonol; Colforsin; HL 362	Adenylate Cyclase FXR Autophagy PKC	Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Forskolin (Coleonol) (GMP) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin (GMP) is also an inducer of intracellular cAMP formation . Forskolin (GMP) induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR . Forskolin (GMP) exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin (GMP) also induces autophagy .

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