Piperitenone oxide
Piperitenone oxide is an orally active monoterpene ketone. Piperitenone oxide can be isolated from the essential oils of plants belonging to Mentha x villosa and Ziziphora clinopodioides. Piperitenone oxide induces differentiation. Piperitenone oxide induces chromosome breakage damage, aneuploidy damage and DNA single-strand breaks. Piperitenone oxide reduces ET-1 levels. Piperitenone oxide exerts antihypertensive effects. Piperitenone oxide can be used in studies related to colon cancer.
For research use only. We do not sell to patients.
- CAS No.: 3564-96-3
- Formula: C10H14O2
- Molecular Weight:166.22
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
Description
In Vitro
Piperitenone oxide (10-150 μM; 24 h) induces chromosome breakage or aneuploidy damage in HepG2 cells, resulting in a statistically significant concentration-dependent increase in micronucleus frequency[2].
Piperitenone oxide (30-150 μM; 24 h) induces single-strand DNA breaks or alkali-labile sites in HepG2 cells, resulting in a statistically significant, concentration-dependent increase in the percentage of DNA tail[2].
Piperitenone oxide (0.03-10 μg/mL; 24 h) dose-dependently inhibits norepinephrine-enhanced ET-1 secretion in primary bovine aortic endothelial cells (BAECs)[3].
Piperitenone oxide (50-100 pmol/L; 24 h) has no effect on NO production in norepinephrine-treated primary bovine aortic endothelial cells (BAECs)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:SHR (male, 12-week-old)[3]
-
Dosage:1 mg/kg; 10 mg/kg; 100 mg/kg
-
Administration:p.o.
-
Result:Reduced systolic blood pressure to 203.1 ± 7.9 mmHg (no significant difference vs.
control SHR) at 1 mg/kg.
Reduced systolic blood pressure to 180.7 ± 8.5 mmHg (p < 0.05 vs.
control SHR) at 10 mg/kg.
Reduced systolic blood pressure to 145.8 ± 7.7 mmHg (p < 0.01 vs.
control SHR) at 100 mg/kg.
Caused a dose-dependent reduction in serum ET-1 levels in SHR.
Chemical Information
-
CAS No. 3564-96-3
-
Molecular Weight 166.22
-
Formula C10H14O2
-
SMILES
O=C1[C@@]2([H])O[C@@]2(C)CC/C1=C(C)/C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Piperitenone oxide Related Classifications
HY-134013 Related Classifications
Powered by Bioz