Piperitenone oxide
Piperitenone oxide is an orally active monoterpene ketone. Piperitenone oxide can be isolated from the essential oils of plants belonging to Mentha x villosa and Ziziphora clinopodioides. Piperitenone oxide induces differentiation. Piperitenone oxide induces chromosome breakage damage, aneuploidy damage and DNA single-strand breaks. Piperitenone oxide reduces ET-1 levels. Piperitenone oxide exerts antihypertensive effects. Piperitenone oxide can be used in studies related to colon cancer.
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- CAS 番号: 3564-96-3
- 分子式: C10H14O2
- 分子量:166.22
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Piperitenone oxide (10-150 μM; 24 h) induces chromosome breakage or aneuploidy damage in HepG2 cells, resulting in a statistically significant concentration-dependent increase in micronucleus frequency[2].
Piperitenone oxide (30-150 μM; 24 h) induces single-strand DNA breaks or alkali-labile sites in HepG2 cells, resulting in a statistically significant, concentration-dependent increase in the percentage of DNA tail[2].
Piperitenone oxide (0.03-10 μg/mL; 24 h) dose-dependently inhibits norepinephrine-enhanced ET-1 secretion in primary bovine aortic endothelial cells (BAECs)[3].
Piperitenone oxide (50-100 pmol/L; 24 h) has no effect on NO production in norepinephrine-treated primary bovine aortic endothelial cells (BAECs)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SHR (male, 12-week-old)[3]
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Dosage:1 mg/kg; 10 mg/kg; 100 mg/kg
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Administration:p.o.
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Result:Reduced systolic blood pressure to 203.1 ± 7.9 mmHg (no significant difference vs.
control SHR) at 1 mg/kg.
Reduced systolic blood pressure to 180.7 ± 8.5 mmHg (p < 0.05 vs.
control SHR) at 10 mg/kg.
Reduced systolic blood pressure to 145.8 ± 7.7 mmHg (p < 0.01 vs.
control SHR) at 100 mg/kg.
Caused a dose-dependent reduction in serum ET-1 levels in SHR.
化学情報
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CAS 番号 3564-96-3
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分子量 166.22
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分子式 C10H14O2
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SMILES
O=C1[C@@]2([H])O[C@@]2(C)CC/C1=C(C)/C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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