Riodipine
Based on 1 Customer Validation
Riodipine (PP-1466) is a vasodilator. Riodipine can be used for the research of antihypertensive.
For research use only. We do not sell to patients.
- Purity : 99.03%
- CAS No.: 71653-63-9
- Formula: C18H19F2NO5
- Molecular Weight:367.34
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
Riodipine;Foridon;PP 1466;PP1466;PP-1466
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
1.6 μM
Compound: Riodipine
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Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
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[PMID: 20966043] |
| HepG2 | EC50 |
1.8 μM
Compound: Riodipine
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Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
| HepG2 | EC50 |
4 μM
Compound: Riodipine
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Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
Chemical Information
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CAS No. 71653-63-9
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Appearance Solid
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Molecular Weight 367.34
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Formula C18H19F2NO5
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Color White to off-white
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SMILES
O=C(OC)C1=C(NC(C)=C(C1C2=CC=CC=C2OC(F)F)C(OC)=O)C
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Synonyms
Foridon; PP-1466
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (272.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7223 mL | 13.6114 mL | 27.2227 mL | 68.0568 mL |
| 5 mM | 0.5445 mL | 2.7223 mL | 5.4445 mL | 13.6114 mL | |
| 10 mM | 0.2722 mL | 1.3611 mL | 2.7223 mL | 6.8057 mL | |
| 15 mM | 0.1815 mL | 0.9074 mL | 1.8148 mL | 4.5371 mL | |
| 20 mM | 0.1361 mL | 0.6806 mL | 1.3611 mL | 3.4028 mL | |
| 25 mM | 0.1089 mL | 0.5445 mL | 1.0889 mL | 2.7223 mL | |
| 30 mM | 0.0907 mL | 0.4537 mL | 0.9074 mL | 2.2686 mL | |
| 40 mM | 0.0681 mL | 0.3403 mL | 0.6806 mL | 1.7014 mL | |
| 50 mM | 0.0544 mL | 0.2722 mL | 0.5445 mL | 1.3611 mL | |
| 60 mM | 0.0454 mL | 0.2269 mL | 0.4537 mL | 1.1343 mL | |
| 80 mM | 0.0340 mL | 0.1701 mL | 0.3403 mL | 0.8507 mL | |
| 100 mM | 0.0272 mL | 0.1361 mL | 0.2722 mL | 0.6806 mL |
Riodipine Related Classifications
HY-118492 Related Classifications
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