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Cat. No.: HY-12718

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(±)-WB 4101

(±)-WB 4101 is a selective α1-Adrenergic receptor antagonist. (±)-WB 4101 can be used in research on urinary system diseases and male reproductive system diseases.

For research use only. We do not sell to patients.

CAS No.: 613-67-2
Formula: C₁₉H₂₃NO₅
Molecular Weight:345.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

(±)-WB 4101 Chemical Structure

CAS No.: 613-67-2

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Other In-stock Forms of (±)-WB 4101

(±)-WB 4101 hydrochloride

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

(±)-WB 4101 is a selective α1-Adrenergic receptor antagonist. (±)-WB 4101 can be used in research on urinary system diseases and male reproductive system diseases^[1]^[2].

IC₅₀ & Target

^[1]

α1-adrenergic receptor

All Adrenergic Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	1 nM Compound: WB 4101	Antagonist activity against human recombinant alpha1 receptor expressed in CHOK1 cells assessed as reduction in epinephrine-induced increase in intracellular Ca2+ levels Antagonist activity against human recombinant alpha1 receptor expressed in CHOK1 cells assessed as reduction in epinephrine-induced increase in intracellular Ca2+ levels	[PMID: 25557493]

In Vitro

(±)-WB 4101 (30 min) is a potent α₁-adrenoceptor antagonist with a pA₂ of 8.83 against norepinephrine in the epididymal segment of isolated rat vas deferens^[1].
(±)-WB 4101 (30 min) antagonizes Clonidine (HY-12721)-induced inhibition of contraction in the prostatic segment of the isolated rat vas deferens, with a pA₂ of 6.29^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 613-67-2
Molecular Weight 345.39
Formula C₁₉H₂₃NO₅
SMILES

COC1=C(OCCNCC2OC3=CC=CC=C3OC2)C(OC)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Giardinà D, et al. Structure-activity relationships for prazosin and WB 4101 analogues as alpha 1-adrenoreceptor antagonists. J Med Chem. 1985 Sep;28(9):1354-7.

[2]. Bolchi C, et al. Structure-affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of alpha 1 antagonist WB-4101. Bioorg Med Chem. 2004 Sep 15;12(18):4937-51.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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