1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Clopamide

Clopamide 

Cat. No.: HY-B1477
Handling Instructions

Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research.

For research use only. We do not sell to patients.

Clopamide Chemical Structure

Clopamide Chemical Structure

CAS No. : 636-54-4

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Description

Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research[1][2].

In Vitro

Clopamide is actively secreted by renal tubular cells and the True Tubular Excretion Fraction (TTEF) value is 10%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The venoconstrictor response to bradykinin is attenuated after oral administration of Clopamide (0.5 mg/kg), and by concomitant local infusion of cyclosporine-A (1-10 μg/min) in conscious dogs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

345.84

Formula

C₁₄H₂₀ClN₃O₃S

CAS No.

636-54-4

SMILES

O=C(NN1[[email protected]](C)CCC[[email protected]@H]1C)C2=CC=C(Cl)C(S(=O)(N)=O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ClopamideSodium ChannelNa channelsNa+ channelsSLC12A3thiazide-likediureticantihypertensivecardiacfailureInhibitorinhibitorinhibit

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Clopamide
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HY-B1477
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