1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Clopamide

Clopamide 

Cat. No.: HY-B1477 Purity: 99.49%
COA Handling Instructions

Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research.

For research use only. We do not sell to patients.

Clopamide Chemical Structure

Clopamide Chemical Structure

CAS No. : 636-54-4

Size Price Stock Quantity
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg USD 80 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Clopamide

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research[1][2].

In Vitro

Clopamide is actively secreted by renal tubular cells and the True Tubular Excretion Fraction (TTEF) value is 10%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The venoconstrictor response to bradykinin is attenuated after oral administration of Clopamide (0.5 mg/kg), and by concomitant local infusion of cyclosporine-A (1-10 μg/min) in conscious dogs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

345.84

Formula

C14H20ClN3O3S

CAS No.
SMILES

O=C(NN1[[email protected]](C)CCC[[email protected]@H]1C)C2=CC=C(Cl)C(S(=O)(N)=O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (722.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8915 mL 14.4576 mL 28.9151 mL
5 mM 0.5783 mL 2.8915 mL 5.7830 mL
10 mM 0.2892 mL 1.4458 mL 2.8915 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.01 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Clopamide
Cat. No.:
HY-B1477
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