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  4. Trichlormethiazide sodium

Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model.

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Trichlormethiazide sodium Chemical Structure

Trichlormethiazide sodium Chemical Structure

CAS No. : 91996-54-2

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Description

Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2].

In Vivo

Trichlormethiazide (1 mg/kg; p.o.; once) sodium increases urinary volume, sodium and potassium excretion in rats[1].
Trichlormethiazide (10 mg/kg, i.v.; daily for 5 days) sodium significantly reduces mean arterial pressure (MAP) within 24 h in high salt intake (HS) rats receiving angiotensin II, but does not affect MAP in any other group[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats, weighing 170-300 g[1]
Dosage: 1 mg/kg
Administration: Oral administration, once
Result: Significantly increased potassium excretion in normal rats. Significantly increased urinary volume, sodium and potassium excretion in cisplatin-induced ARF (acute renal failures) rats.
Animal Model: Male Sprague-Dawley rats (350-450 g)[2]
Dosage: 10 mg/kg
Administration: Intravenous injection, daily, for 15 days
Result: Produced a significant fall in MAP in rats on combined angiotensin II and high salt intake.
Molecular Weight

403.65

Formula

C8H8Cl3N3NaO4S2
CAS No.
SMILES

O=S(C1=C(Cl)C=C(C2=C1)NC(C(Cl)Cl)NS2(=O)=O)(N)=O.[Na]
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Keywords:

Trichlormethiazide91996-54-2OthersdiureticantihypertensiveangiotensinIIhypertensionacute renal failuresInhibitorinhibitorinhibit

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