1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Spirapril hydrochloride

Spirapril hydrochloride (Synonyms: SCH 33844 hydrochloride)

Cat. No.: HY-A0230A
Handling Instructions

Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure.

For research use only. We do not sell to patients.

Spirapril hydrochloride Chemical Structure

Spirapril hydrochloride Chemical Structure

CAS No. : 94841-17-5

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Description

Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1].

IC50 & Target

IC50: angiotensin converting enzyme[1]

In Vivo

Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TGM123 mice (expressing a rat angiotensinogen transgene) and TLM ( lacking the angiotensinogen gene) mice[2]
Dosage: 10 mg/kg
Administration: Feeding needle; 10 mg/kg; 3 weeks
Result: Alter voluntary alcohol consumption in animals.
Crossed the blood-brain barrier and may influences alcohol consumption mainly by decreasing central angiotensin II (AII) levels.
Molecular Weight

503.07

Formula

C₂₂H₃₁ClN₂O₅S₂

CAS No.
SMILES

O=C([[email protected]](C1)N(C([[email protected]@H](N[[email protected]](C(OCC)=O)CCC2=CC=CC=C2)C)=O)CC31SCCS3)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SpiraprilSCH 33844SCH33844SCH-33844Angiotensin-converting Enzyme (ACE)hypertensionheart failureACEantihypertensiveInhibitorinhibitorinhibit

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Product Name:
Spirapril hydrochloride
Cat. No.:
HY-A0230A
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