2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Spirapril hydrochloride

Spirapril hydrochloride  (Synonyms: SCH 33844 hydrochloride)

Cat. No.: HY-A0230A Purity: ≥97.0%
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Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active proagent of Spiraprilat and can be used for the research of hypertension, congestive heart failure.

For research use only. We do not sell to patients.

Spirapril hydrochloride Chemical Structure

Spirapril hydrochloride Chemical Structure

CAS No. : 94841-17-5

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5 mg USD 310 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Spirapril hydrochloride:

Spirapril hydrochloride Related Antibodies

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Description

Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active proagent of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1].

IC50 & Target

IC50: angiotensin converting enzyme[1]
In Vivo

Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TGM123 mice (expressing a rat angiotensinogen transgene) and TLM ( lacking the angiotensinogen gene) mice[2]
Dosage: 10 mg/kg
Administration: Feeding needle; 10 mg/kg; 3 weeks
Result: Alter voluntary alcohol consumption in animals.
Crossed the blood-brain barrier and may influences alcohol consumption mainly by decreasing central angiotensin II (AII) levels.
Molecular Weight

503.07

Formula

C22H31ClN2O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](C1)N(C([C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)C)=O)CC31SCCS3)O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9878 mL 9.9390 mL 19.8779 mL
5 mM 0.3976 mL 1.9878 mL 3.9756 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9878 mL 9.9390 mL 19.8779 mL 49.6949 mL
5 mM 0.3976 mL 1.9878 mL 3.9756 mL 9.9390 mL
10 mM 0.1988 mL 0.9939 mL 1.9878 mL 4.9695 mL
15 mM 0.1325 mL 0.6626 mL 1.3252 mL 3.3130 mL
20 mM 0.0994 mL 0.4969 mL 0.9939 mL 2.4847 mL
25 mM 0.0795 mL 0.3976 mL 0.7951 mL 1.9878 mL
30 mM 0.0663 mL 0.3313 mL 0.6626 mL 1.6565 mL
40 mM 0.0497 mL 0.2485 mL 0.4969 mL 1.2424 mL
50 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9939 mL
60 mM 0.0331 mL 0.1656 mL 0.3313 mL 0.8282 mL
80 mM 0.0248 mL 0.1242 mL 0.2485 mL 0.6212 mL
100 mM 0.0199 mL 0.0994 mL 0.1988 mL 0.4969 mL
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Spirapril hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spirapril94841-17-5SCH 33844SCH33844SCH-33844Angiotensin-converting Enzyme (ACE)hypertensionheart failureACEantihypertensiveInhibitorinhibitorinhibit

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