LY127210 free base
LY127210 free base is an orally active peripheral arterial vasodilating antihypertensive agent. LY127210 free base interferes with the baroreflex mechanism, exerts direct myocardial bradycardic activity, has no α or β receptor blocking properties, and acts via all conventional administration routes. LY127210 free base reduces vascular resistance, cardiac output, heart rate, left ventricular end-diastolic pressure, regional vascular resistance, as well as blood flow in the skin and cerebral cortex. LY127210 free base can be used in research related to hypertension.
For research use only. We do not sell to patients.
- CAS No.: 57184-68-6
- Formula: C12H14N2O2
- Molecular Weight:218.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SHR (male, 16-18 weeks old, 280-330g, anesthetized with methohexital followed by α-chloralose infusion)[1]
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Dosage:10 mg/kg
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Administration:i.p.; single dose
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Result:Reduced mean arterial pressure by 35% from baseline at 5 minutes post-dosing.
Reduced systemic vascular resistance by 26% from baseline at 5 minutes post-dosing.
Reduced left ventricular end-diastolic pressure by 41% from baseline at 5 minutes post-dosing.
Decreased heart rate by 4% from baseline at 5 minutes post-dosing, with an additional 2% decrease at 20 minutes post-dosing.
Decreased skin blood flow by 30% and cerebral cortex blood flow by 16%.
Reduced vascular resistance in kidney, cerebral cortex, ileum, and skin.
Produced non-significant decreases in cardiac output, stroke volume, and LVdP/dt max at 5 minutes post-dosing.
Maintained all hemodynamic changes for at least 20 minutes post-dosing.
Chemical Information
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CAS No. 57184-68-6
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Molecular Weight 218.25
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Formula C12H14N2O2
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SMILES
NC1=NC=CC2=CC(OC)=C(OC)C=C2C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY127210 free base Related Classifications
HY-129706 Related Classifications
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