2. Disease Areas
  3. Blood or Cardio-cerebrovascular Disease
  4. Cardiovascular Disease
  5. Hypertension
  6. LY127210 free base

LY127210 free base is an orally active peripheral arterial vasodilating antihypertensive agent. LY127210 free base interferes with the baroreflex mechanism, exerts direct myocardial bradycardic activity, has no α or β receptor blocking properties, and acts via all conventional administration routes. LY127210 free base reduces vascular resistance, cardiac output, heart rate, left ventricular end-diastolic pressure, regional vascular resistance, as well as blood flow in the skin and cerebral cortex. LY127210 free base can be used in research related to hypertension.

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LY127210 free base

LY127210 free base Chemical Structure

CAS No. : 57184-68-6

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LY127210 free base Related Antibodies

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Description

LY127210 free base is an orally active peripheral arterial vasodilating antihypertensive agent. LY127210 free base interferes with the baroreflex mechanism, exerts direct myocardial bradycardic activity, has no α or β receptor blocking properties, and acts via all conventional administration routes. LY127210 free base reduces vascular resistance, cardiac output, heart rate, left ventricular end-diastolic pressure, regional vascular resistance, as well as blood flow in the skin and cerebral cortex. LY127210 free base can be used in research related to hypertension[1][2].

In Vivo

LY127210 (10 mg/kg; i.p.; single dose) free base reduces mean arterial pressure by 35% in chloralose-anesthetized spontaneously hypertensive rats via a 26% reduction in systemic vascular resistance and a smaller reduction in cardiac output, without inducing reflex tachycardia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SHR (male, 16-18 weeks old, 280-330g, anesthetized with methohexital followed by α-chloralose infusion)[1]
Dosage: 10 mg/kg
Administration: i.p.; single dose
Result: Reduced mean arterial pressure by 35% from baseline at 5 minutes post-dosing.
Reduced systemic vascular resistance by 26% from baseline at 5 minutes post-dosing.
Reduced left ventricular end-diastolic pressure by 41% from baseline at 5 minutes post-dosing.
Decreased heart rate by 4% from baseline at 5 minutes post-dosing, with an additional 2% decrease at 20 minutes post-dosing.
Decreased skin blood flow by 30% and cerebral cortex blood flow by 16%.
Reduced vascular resistance in kidney, cerebral cortex, ileum, and skin.
Produced non-significant decreases in cardiac output, stroke volume, and LVdP/dt max at 5 minutes post-dosing.
Maintained all hemodynamic changes for at least 20 minutes post-dosing.
Molecular Weight

218.25

Formula

C12H14N2O2
CAS No.
SMILES

NC1=NC=CC2=CC(OC)=C(OC)C=C2C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Keywords:

LY12721057184-68-6LY 127210LY-127210Othersreflex tachycardiavascular resistanceleft ventricular end-diastolic pressurehypertensionheart ratemean arterial pressurecardiac outputcerebral cortexbaroreflex mechanismsspontaneously hypertensive ratsInhibitorinhibitorinhibit

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