57184-68-6
Chemical Structure
LY127210 free base
- CAS No.: 57184-68-6
- Formula:C12H14N2O2
- Molecular Weight:218.25
IUPAC Name: 7,8-dimethoxy-1H-benzo[d]azepin-2-amine
InChIKey: WADYQLCXAVXCQZ-UHFFFAOYSA-N
SMILES: NC1=NC=CC2=CC(OC)=C(OC)C=C2C1
Biological Activity: LY127210 free base is an orally active peripheral arterial vasodilating antihypertensive agent. LY127210 free base interferes with the baroreflex mechanism, exerts direct myocardial bradycardic activity, has no α or β receptor blocking properties, and acts via all conventional administration routes. LY127210 free base reduces vascular resistance, cardiac output, heart rate, left ventricular end-diastolic pressure, regional vascular resistance, as well as blood flow in the skin and cerebral cortex. LY127210 free base can be used in research related to hypertension[1][2].
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LY127210 free base | LY127210 free base is an orally active peripheral arterial vasodilating antihypertensive agent. LY127210 free base interferes with the baroreflex mechanism, exerts direct myocardial bradycardic activity, has no α or β receptor blocking properties, and acts via all conventional administration routes. LY127210 free base reduces vascular resistance, cardiac output, heart rate, left ventricular end-diastolic pressure, regional vascular resistance, as well as blood flow in the skin and cerebral cortex. LY127210 free base can be used in research related to hypertension. | |||||||||||||||||||||
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[1]. Steinberg MI, et al. Hemodynamic and vascular activity of LY127210, a new vasodilator, in anesthetized spontaneously hypertensive rats: comparison with hydralazine. Clin Exp Hypertens A. 1985;7(10):1481-97.
- [2]. Ruffolo RR Jr, et al. Evaluation of a novel antihypertensive agent, LY127210, in anesthetized and conscious spontaneously hypertensive rats. J Pharmacol Exp Ther. 1985 Jan;232(1):134-8. [Content Brief]
Keywords
