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STOCK2S-26016 

Cat. No.: HY-112143
Handling Instructions

STOCK2S-26016 is a WNK signalling inhibitors. STOCK2S-26016 inhibits WNK4 and WNK1 with IC50s of 16 μM and 34.4 μM, respectively. STOCK2S-26016 has potential for antihypertensive research.

For research use only. We do not sell to patients.

STOCK2S-26016 Chemical Structure

STOCK2S-26016 Chemical Structure

CAS No. : 332922-63-1

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Description

STOCK2S-26016 is a WNK signalling inhibitors. STOCK2S-26016 inhibits WNK4 and WNK1 with IC50s of 16 μM and 34.4 μM, respectively. STOCK2S-26016 has potential for antihypertensive research[1].

IC50 & Target

IC50: 16 μM (WNK4); 34.4 μM (WNK1)[1]

In Vitro

STOCK2S-26016 (10 and 30 minutes) blocks the effect of L-NAME on phosphorylated sodium-chloride cotransporter (NCC) in mDCT cells[2].
STOCK2S-26016 (25-200 μM) drastically and dose-dependently reduces the phosphorylation of STE20/SPS1-related proline/alanine-rich protein kinase (SPAK) and NCC in mpkDCT cells[1].
STOCK2S-26016 (50-200 μM) drastically and dose-dependently reduces the phosphorylation of SPAK and Na/K/Cl cotransporter 1 (NKCC1) in MOVAS cells[1].

Molecular Weight

333.38

Formula

C₂₀H₁₉N₃O₂

CAS No.

332922-63-1

SMILES

NC1=C(C=CC(NCC2=CC=CO2)=C3)C3=NC4=CC=C(OCC)C=C41

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

STOCK2S-26016OthersWNKWNK4WNK1antihypertensionSPAKInhibitorinhibitorinhibit

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