WNK1
WNK1 gave its family the name 'with no lysine (K)' because the catalytic lysine sits in beta-strand 2 instead of the canonical position in strand 3. This chloride-sensitive kinase is expressed widely, with a neuron-specific long isoform, and controls ion homeostasis by activating the STE20-family kinases SPAK and OSR1, which in turn phosphorylate the cotransporters NCC, NKCC1 and NKCC2. WNK1 also regulates potassium efflux channels and cell-volume responses. Deletions in WNK1 intron 1 cause pseudohypoaldosteronism type II (Gordon syndrome) with hypertension and hyperkalemia, while mutations affecting the neuron-specific isoform underlie hereditary sensory neuropathy type 2. Recombinant WNK1 supports ion-transport research.
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WNK1 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
